著者

Jinlong Cheng Bolin Chen

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.45, pp.45-56, 2015-03-30 (Released:2017-06-01)

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Cerebrovascular disease is a kind of complications in diabetes mellitus which is induced by suger, fat and protein metabolic disorder. These series of nutrient metabolic disorder can lead to intracranial large blood vessels and microvascular lesions. About 20-40 percent of type 2 diabetes patients will suffer from cerebrovascular diseases which become the main causes of death in diabetic patients. Recently many kinds of pathogenesis have been found by researchers about cerebrovascular diseases in diabetes mellitus such as hyperglycemia, insulin resistance, endothelial cell dysfunction, abnormal lipids metabolism and so on. The major clinical manifestations of diabetic cerebrovascular diseases are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel diseases and acute cerebral vascular diseases. This article will introduce the pathogenesis and clinical features of diabetic cerebrovascular diseases in detail. We will also focus on its latest research progress.