- 著者
- Jinlong Cheng Bolin Chen
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.45, pp.45-56, 2015-03-30 (Released:2017-06-01)
Cerebrovascular disease is a kind of complications in diabetes mellitus which is induced by suger, fat and protein metabolic disorder. These series of nutrient metabolic disorder can lead to intracranial large blood vessels and microvascular lesions. About 20-40 percent of type 2 diabetes patients will suffer from cerebrovascular diseases which become the main causes of death in diabetic patients. Recently many kinds of pathogenesis have been found by researchers about cerebrovascular diseases in diabetes mellitus such as hyperglycemia, insulin resistance, endothelial cell dysfunction, abnormal lipids metabolism and so on. The major clinical manifestations of diabetic cerebrovascular diseases are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel diseases and acute cerebral vascular diseases. This article will introduce the pathogenesis and clinical features of diabetic cerebrovascular diseases in detail. We will also focus on its latest research progress.
- 著者
- Bolin Chen
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.42, pp.52-61, 2013-09-30 (Released:2017-06-01)
Intracerebral transplantation is a new therapy of neurological disorders. Among them the intracerebral transplantation of stem cells is a hot spot of international medical research. There are many methods of intracerebral transplantation of stem cells such as intraparenchymal transplantation, transplantation by the blood circulation injection, transplantation by cerebrospinal fluid injection and so on. The three methods have different characters and each of them has its advantages and disadvantages. In addition to this, the blood-brain barrier limits the use of the intracerebral transplantation of stem cells. Therefore several measures should be taken to increase the permeability of blood-brain barrier. This article will discuss the methods of the intracerebral transplantation of stem cells and openning methods of the permeability of blood-brain barrier.
- 著者
- Bolin Chen Norio Mori
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.43, pp.43-49, 2014-05-30 (Released:2017-06-01)
Neural stem cells(NSCs) are a kind of cells, which come from nerve tissue with self-renewal and potentials of multiple differentiations. Applications of NSCs for therapy of neurological conditions, such as Parkinson's disease, Alzheimer's disease, or stroke, are particularly appealing as damage of the central nervous system is irreversible and the efficacy of conventional therapy is limited. With the development of molecular imaging, tracking and detection of transplanted NSCs have become a breakthrough of recent studies. Recent studies have focused on the application of functional magnetic resonance imaging(fMRI) to trace and detect NSCs. This article will discuss the application of fMRI on the tracking and detection of NSCs after transplantation.