- 著者
- KEIICHI KAMIJO
- 出版者
- The Japan Endocrine Society
- 雑誌
- Endocrine Journal (ISSN:09188959)
- 巻号頁・発行日
- vol.41, no.1, pp.19-23, 1994 (Released:2006-11-21)
- 参考文献数
- 9
- 被引用文献数
- 9 14
The purpose of the present study is to investigate by a computed tomography (CT) thyroid CT number (Hounsfield units; H.U.) in chronic thyroiditis (CH).The correlation of the CT value with the concentration of KI solution in the test tube of thyroid phantom for thyroid scintigram was linear. No significant correlation between thyroid CT number and the urinary iodine concentration was also observed in 36 patients with CH. A mean thyroid CT number (±SD) of 81±24 H.U. in 155 patients with CH was significantly (P<0.001) lower than 125±18 H.U. in 95 normal subjects. The patients with CH could be arbitrarily divided into 3 groups according to the decrease in their thyroid CT number: normal (N) group (_??_88 H.U.), moderately decreased (MD) group (70-87 H.U.) and the greately decreased (GD) group (<70 H.U.). There was a significant difference in the thyroid volume among 21.2±9.1cm3 in the N group, 32.2±18.1 in the MD group (P<0.05 vs. N group) and 43.6±23.3 in the GD group (P<0.01 vs. N and MD group). The mean serum TSH concentration of 38.95±54.61μU/ml in the SD group was significantly (P<0.01) higher than either 4.11±3.64 in the MD group or 2.00±1.43 in the N group. The serum TSH level in the MD group differed significantly (P<0.05) from that of the N group.Hypothyroidism characterized by low serum FT4 (<0.8ng/dl) and very high serum TSH was observed in none in the N group, in 2 (7.1%) of 28 cases in the MD group and in 16 (33.3%) of 48 cases in the GD group. And latent hypothyroidism characterized by an increase in serum TSH levels (_??_5μU/ml) and normal concentrations of thyroid hormones was found in 2 (5.1%) of 39 cases in the N group, 5 (17.9%) in the MD group and 16 (33.3%) of the GD group. There was a significant (P<0.005) difference in multiple chi-square analysis in the comparison between the GD group and the N group or MD group. The frequency of higher titers of antimicrosomal Ab and antithyroglobulin Ab seemed to be correlated with the amount of decrease in the thyroid CT number. In conclusion, there was a significant correlation between the thyroid CT number and the severity of chronic thyroiditis.
- 著者
- KEIICHI KAMIJO
- 出版者
- The Japan Endocrine Society
- 雑誌
- Endocrine Journal (ISSN:09188959)
- 巻号頁・発行日
- vol.41, no.1, pp.25-30, 1994 (Released:2006-11-21)
- 参考文献数
- 13
- 被引用文献数
- 6 7
The purpose of the present study was to investigate by a computed tomography (CT) the Hounsfield unit (H.U.) of the thyroid in hyperthyroid and euthyroid Graves' disease and destructive thyrotoxicosis.The mean thyroid CT number in 95 controls was 122±18 H.U. (±SD) and did not change significantly with advancing age. The mean thyroid CT number (±SD) of 85±22 H.U. in 60 patients with hyperthyroid Graves' disease was significantly (P <0.001) lower than either in normal controls or 116± 22 H.U. in 11 patients with euthyroid Graves' disease (P<0.001). Comparison of thyroid hormones and TSH receptor Ab values of untreated patients with a normal and an abnormally low thyroid CT number showed that serum total and free T3 were significantly (P <0.05) higher in the latter group than in the former group. With respect to the effect of methimazol (MMI) on the thyroid CT number, in the untreated 10 patients with a low thyroid CT number, the initial mean CT number was 65±11 H.U. and increased significantly (P<0.05) to 76± 14 H.U. after treatment with MMI. In contrast, in 6 patients with a normal thyroid CT number prior to therapy, the initial mean thyroid CT number was 102±11 H.U. and fell significantly (P<0.05) to 84±16 H.U. after treatment with MMI.The thyroid CT number in destructive thyrotoxicosis is markedly decreased to less than 70 H.U. and the mean values of 57±7 H.U. in 6 patients with silent thyroiditis and of 61±5 H.U. in 7 with subacute thyroiditis differ significantly (P<0.001) from Graves' disease. In conclusion, the thyroid CT number is significantly reduced in hyperthyroid Graves' disease, normal in euthyroid Graves' disease and markedly decreased in destructive thyrotoxicosis. The high T3 value seemed to play an important role in the pathogenesis of a decline in the thyroid CT number in Graves' disease. An antithyroid drug therapy caused two different changes in the thyroid CT number, depending on whether the thyroid CT number prior to therapy was normal or low.