著者

HISAO EKIMOTO KINIIHIKO TAKADA KATSUTOSHI TAKAHASHI AKIRA MATSUDA TOMOHISA TAKITA HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.37, no.6, pp.659-663, 1984 (Released:2006-04-19)

参考文献数

30

被引用文献数

7 5

---

The pulmonary fibrosis caused by peplomycin (PEP) was studied in terms of oxygen toxicity using ICR mice. When 16μg of PEP was administered intratracheally in mice after exposure to the air containing 75% O2 for 10 days, the pulmonary fibrosis was completely suppressed, while when mice were exposed to 75% O2 after the administration of PEP, the fibrosis was much severe than that of mice raised in atmospheric air. In 50% O2 similar oxygen effect was also observed, but it was weaker than that in 75% O2. In 90% O2 the oxygen toxicity was observed in mice without administration of PEP. When mice were exposed to 75% O2 the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, which are relevant to the detoxication of active oxygen species, were not increased in the lung, but the levels of reducing agents such as glutathione and ascorbic acid, and high molecular substances having 1O2-scavenging activity were enhanced. The results suggest that these materials have some roles to decrease the pulmonary fibrosis caused by PEP.