著者
HIROSHI SANO TOSHIAKI SUNAZUKA HARUO TANAKA KINYA YAMASHITA RYO OKACHI SATOSHI OMURA
出版者
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
雑誌
The Journal of Antibiotics (ISSN:00218820)
巻号頁・発行日
vol.38, no.10, pp.1350-1358, 1985 (Released:2006-04-19)
参考文献数
5
被引用文献数
6 10

3, 3"-Di-O-acyl-4"-O-sulfonyl and 3, 3"-di-O-acyl-4"-O-alkyl derivatives of spiramycin I were synthesized and evaluated by four parameters, antibacterial activity, affinity to ribosomes, lypophilicity and therapeutic effects. Among them, 3, 3"-di-O-acetyl-4"-O-mesyl and 3, 3"-di-O-acetyl-4"-O-methylspiramycin I having relatively small substituents at 4"-position were the most effective in mouse protection tests, and the results were comparable to acetylspiramycin.