1 0 0 0 OA Whole-body retention and fetal uptake of ^<65>Zn in pregnant mice fed a Zn-deficient diet
- 著者
- 松坂 尚典 SAKAMOTO HIDEKI SATO ITARU SHINAGAWA KUNIHIRO KOBAYASHI HARUO NISHIMURA YOSHIKAZU
- 出版者
- 日本放射線影響学会
- 雑誌
- Journal of radiation research (ISSN:04493060)
- 巻号頁・発行日
- vol.36, no.3, pp.196-202, 1995-09
- 被引用文献数
- 2
Whole-body retention and fetal uptake of ^<65>5Zn under a Zn-deficient diet were studied in pregnant mice in the late gestational stage after a single oral administration of ^<65>Zn. Whole-body retentions were much greater in mice given a Zn-deficient diet than in those given a Zn-normal diet. Accordingly, the amount of ^<65>Zn transmitted to the offspring in utero was greater in the Zn-deficient diet group. In another experiment, fetal uptake of ^<65>Zn in dams on gestation day 17 was examined over a period of 24 hr after a single intravenous administration of ^<65>Zn to the Zn-deficient and Zn-normal animals. There was no major difference in fetal uptake between the two groups, indicative that approximately a similar proportion of the ^<65>Zn retained in the maternal body was transmitted to the in utero offspring in both groups.