- 著者
- Kai Yang Xuejun Jiang Shuqun Cheng Chengzhi Chen Xianqing Cao Baijie Tu
- 出版者
- (公社)日本産業衛生学会
- 雑誌
- Journal of Occupational Health (ISSN:13419145)
- 巻号頁・発行日
- vol.59, no.1, pp.1-7, 2017-01-20 (Released:2017-01-24)
- 参考文献数
- 27
- 被引用文献数
- 21
Objective: To evaluate the effects of occupational exposures to coke oven emissions (COEs) and benzo[a]pyrene (B[a]P) on the prevalence of hypertension and abnormal electrocardiogram (ECG) in coke oven workers. Methods: We included 880 coke oven workers and 710 oxygen employees in the exposed and control groups, respectively. Blood pressure (BP), ECG, blood lipid levels, and glucose levels of all subjects were measured. COE and B[a]P concentrations at the bottom, side, and top of the oven and control plants were estimated by weighing and high-performance liquid chromatography. Results: The COE concentration at the top and side was higher than that at the bottom (P < 0.05). The levels of B[a]P at the top and side significantly exceeded the limit value. Abnormal BP, ECG, the detection ratio of hypertension and left ventricular high voltage were significantly greater in the exposed group than in the control group (P < 0.05). The logistic regression analysis results revealed that age and B[a]P exposure were risk factors for hypertension in coke oven workers (P < 0.05) and both were risk factors for abnormal ECG (P < 0.05). Moreover, B[a]P exposure, age, and gender were risk factors for impaired fasting glucose in coke oven workers (P < 0.05). Conclusions: B[a]P and COE exposures are risk factors for hypertension and abnormal ECG in coke oven workers.
- 著者
- Qin-Fan LI Cai-Ju HAO Yong-Ping XU Jie LIANG Kai YANG Zhong-Hua CUI
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.1203220797, (Released:2012-03-26)
- 被引用文献数
- 5 8
By a series of experiments, we identified a new member of locoweed family, Oxytropis serioopetala, which produces swainsonine, a phytotoxin harmful to livestock. In order to evaluate the toxicity of Oxytropis serioopetala, its extract was administered to ten rabbits by gavage at a dose of 1.5 mg/kg body weight as swainsonine once daily. After the 20th day, the rabbits appeared depressive and anorexia. Besides, intention tremors were apparent upon move. Their eyes were dull. The rear limbs were severely weak and even progressed to partial paresis. Activities of serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (AKP) and urea nitrogen (BUN) levels in the poisoned rabbits increased significantly. Serum α-mannosidase (AMA) activity decreased markedly. Pathomorphological lesions in the locoweed-poisoned rabbits developed severe microvacuolation of visceral and neurological tissue. The extensive vacuolation was observed in liver, kidney and brain. These clinical and pathological features are similar to the symptoms of locoism.