文献一覧: Kanako ISHIHARA (著者)

4 0 0 0 OA Contribution of the AcrAB-TolC Efflux Pump to High-Level Fluoroquinolone Resistance in Escherichia coli Isolated from Dogs and Humans

著者: Toyotaka SATO Shin-ichi YOKOTA Torahiko OKUBO Kanako ISHIHARA Hiroshi UENO Yasukazu MURAMATSU Nobuhiro FUJII Yutaka TAMURA
出版者: 公益社団法人日本獣医学会
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.12-0186, (Released:2012-11-14)
被引用文献数: 8 30

Fluoroquinolone resistance is mainly caused by mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV in Escherichia coli. The AcrAB-TolC efflux pump contributes to resistance against fluoroquinolone and other antimicrobials. In this study, we investigated a high-level mechanism of fluoroquinolone resistance in E. coli that was isolated from human clinical samples and canine fecal samples. E. coli strains with high levels of fluoroquinolone resistance have been found to be frequently resistant to cephalosporins. Strains with high-level fluoroquinolone resistance exhibited lower intracellular enrofloxacin (ENR) concentrations, higher expression of AcrA, and a greater reduction in the fluoroquinolone minimum inhibitory concentration for treatment with an efflux pump inhibitor. The frequency of strains with enhanced ENR resistance selection and the survival rate of E. coli in the presence of ENR in vitro were correlated well with AcrA protein expression levels in the parental strains. These results suggest that AcrAB-TolC efflux pump over-expression is related to high-level fluoroquinolone resistance and the selection of strains with enhanced fluoroquinolone resistance.

2012-11-14 22:54:59
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2 0 0 0 OA Epidemiological analysis of methicillin-resistant Staphylococcus aureus carriage among veterinary staff of companion animals in Japan

著者: Kanako ISHIHARA Mieko SAITO Natsumi SHIMOKUBO Yasukazu MURAMATSU Shigeki MAETANI Yutaka TAMURA
出版者: 公益社団法人日本獣医学会
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.14-0119, (Released:2014-10-05)
被引用文献数: 1

Veterinary staff carrying methicillin-resistant Staphylococcus aureus (MRSA) can be a source of MRSA infection in animals. To identify risk factors of MRSA carriage among veterinary staff, MRSA carriage and epidemiological information (sex, career, contact with MRSA-identified animal patients and others) were analyzed from 96 veterinarians and 70 veterinary technicians working at 71 private veterinary clinics in Japan. Univariate analysis determined sex (percentage of MRSA carriage, male (29.2%) vs. female (10.0%); P=0.002) and career (veterinarians (22.9%) vs. veterinary technicians (10.0%); P=0.030) as risk factors. Multivariable analysis revealed that sex was independently associated with MRSA carriage (adjusted odds ratio, 3.717; 95% confidence interval, 1.555–8.889; P=0.003). Therefore, male veterinary staff had a higher risk of MRSA carriage than female staff.

2014-10-06 19:51:23
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1 0 0 0 OA Role of multidrug resistance and co-resistance on a high percentage of streptomycin resistance in Escherichia coli isolated from chicken meats in Japan

著者: Thein LIN Shizuka NOMURA Suzuka SOMENO Takahiro ABE Miyuki NISHIYAMA Shunya SHIKI Hayato HARIMA Kanako ISHIHARA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.85, no.8, pp.832-836, 2023 (Released:2023-08-01)
参考文献数: 25

We focused on streptomycin resistance because of the high percentage of streptomycin-resistant Escherichia coli concerning the amount used of streptomycin. Antimicrobial resistance and horizontal transfer were identified in 117 isolates of coliform bacteria from chicken meat to identify the factors that increase streptomycin resistance. Escherichia (45 isolates) was the predominant genus. Most streptomycin-resistant Escherichia isolates were resistant to other antimicrobials (17/18), suggesting that using various antimicrobials could select streptomycin-resistant Escherichia isolates. Resistance was transferred from 7 out of the 18 streptomycin-resistant isolates. The transconjugants acquired strA/strB (7/7), blaTEM (5/7), aphA1 (5/7), tetB (3/7), dfrA14 (1/7) and/or dfrA17 (1/7). The co-resistance of streptomycin resistance with other resistances would also increase streptomycin resistance.

2023-08-03 05:07:08
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1 0 0 0 OA Role of multidrug resistance and co-resistance on a high percentage of streptomycin resistance in Escherichia coli isolated from chicken meats in Japan

著者: Thein LIN Shizuka NOMURA Suzuka SOMENO Takahiro ABE Miyuki NISHIYAMA Shunya SHIKI Hayato HARIMA Kanako ISHIHARA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.23-0135, (Released:2023-06-20)

2023-06-20 08:48:55
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1 0 0 0 OA Contribution of the AcrAB-TolC Efflux Pump to High-Level Fluoroquinolone Resistance in Escherichia coli Isolated from Dogs and Humans

著者: Toyotaka SATO Shin-ichi YOKOTA Torahiko OKUBO Kanako ISHIHARA Hiroshi UENO Yasukazu MURAMATSU Nobuhiro FUJII Yutaka TAMURA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.75, no.4, pp.407-414, 2013 (Released:2013-05-02)
参考文献数: 38
被引用文献数: 17 30

2013-05-04 02:04:11
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