著者

Yumi KONDO Kazuaki TAKASHIMA Satoshi MATSUMOTO Masahiro SHIBA Tomoko OTSUKI Gen KINOSHITA Joseph ROSENTEL Sheila J. GROSS Candis FLEISHMAN Yoshihisa YAMANE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.10, pp.1283-1289, 2012 (Released:2012-11-02)

参考文献数

18

被引用文献数

3 11 1

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Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator’s judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.

著者

Masahiko TAKENAKA Kazuaki TAKASHIMA Hajimu KURUMATANI Nobutaka IDA Reeko SATO Yoshihisa YAMANE

出版者

動物臨床医学会

雑誌

動物臨床医学 (ISSN:13446991)

巻号頁・発行日

vol.20, no.4, pp.131-139, 2011-12-31 (Released:2012-12-18)

参考文献数

30

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Objective : Since the sensitivity to prostacyclin differs widely depending on the animal species, it is essential to investigate the dose setting from the safety point of view before using beraprost (BPS) in diseased cats.Design : One week multiple administration toxicity study of BPS (10, 30, 70, 100 μg/kg, twice a day) compared with vehicle as control.Procedure : BPS group (n=6) at 10, 30, 70 and 100 μg/kg and vehicle group (n=5) were administered to healthy cats twice a day for 7 days. Both in BPS and vehicle groups, cessation period of the drug was provided 2 weeks between each doses of BPS. In addition hemodynamic parameters were also noted at 0.5 hour before initial administration on the first day and at 1 hour after final administration on the 7th day of each dose of BPS and vehicle.Results : Though BPS from 30 μg/kg upward transiently and dose-dependently increased the heart rate but had no influence on the blood pressure. Compared with the vehicle group, serum creatinine slightly but significantly decreased at 70 and 100 μg/kg and this decrease was also significant against the pre-administration value at the same dose. The influence of BPS on the blood parameters was nil or negligible, if any. Diarrhea were sporadically noted at 70 μg/kg, and mild and transient vomiting and sedation occurred at 100 μg/kg. However, each symptom soonerly disappeared without treatment.Conclusion : The pharmacological action and types of adverse effects of BPS in the cats were almost similar to those observed in other animals and the repeated oral administration of BPS can be safely conducted in cats at least up to 30 μg/kg twice a day.

著者

Kiwamu HANAZONO Shinya FUKUMOTO Kazuko HIRAYAMA Kazuaki TAKASHIMA Yoshihisa YAMANE Masahiro NATSUHORI Tsuyoshi KADOSAWA Tsuyoshi UCHIDE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.11, pp.1477-1482, 2012 (Released:2012-12-01)

参考文献数

22

被引用文献数

3 9 1

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Gastrointestinal stromal tumor (GIST), a mesenchymal neoplasm affecting the gastrointestinal tract, shows a variety of clinical behaviors from inactive benign to aggressive malignant in dogs. In this study, the feasibility of using clinically significant ultrasonographic features to predict the metastatic potential of canine GIST was investigated through comparison with actual metastatic incidence and findings of malignancy obtained by postoperative pathological examination. Ultrasonographic features, including large tumor size, irregular margin and heterogeneous internal echogenicity with large hypoechoic areas, related closely with the presence of metastasis as well as a high-risk ranking by the human classification system according to pathological findings. Based on these ultrasonographic features, the potential of metastasis in canine GIST could be preoperatively predicted.

著者

Kiwamu HANAZONO Shinya FUKUMOTO Kazuko HIRAYAMA Kazuaki TAKASHIMA Yoshihisa YAMANE Masahiro NATSUHORI Tsuyoshi KADOSAWA Tsuyoshi UCHIDE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.11-0553, (Released:2012-06-08)

被引用文献数

3 9

---

Gastrointestinal stromal tumor (GIST), a mesenchymal neoplasm affecting the gastrointestinal tract, shows a variety of clinical behaviors from inactive benign to aggressive malignant in dogs. In this study, the feasibility of using clinically significant ultrasonographic features to predict the metastatic potential of canine GIST was investigated through comparison with actual metastatic incidence and findings of malignancy obtained by postoperative pathological examination. Ultrasonographic features, including large tumor size, irregular margin and heterogeneous internal echogenicity with large hypoechoic areas, related closely with the presence of metastasis as well as a high-risk ranking by the human classification system according to pathological findings. Based on these ultrasonographic features, the potential of metastasis in canine GIST could be preoperatively predicted.

著者

Yumi KONDO Kazuaki TAKASHIMA Satoshi MATSUMOTO Masahiro SHIBA Tomoko OTSUKI Gen KINOSHITA Joseph ROSENTEL Sheila J. GROSS Candis FLEISHMAN Yoshihisa YAMANE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.11-0306, (Released:2012-05-31)

被引用文献数

3 11

---

Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator’s judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.