著者

Kazuki Yamada Hiroaki Yaguchi Kaede Ishikawa Daiki Tanaka Yuki Oshima Keiichi Mizushima Hisashi Uwatoko Shinichi Shirai Ikuko Iwata Masaaki Matsushima Keiko Tanaka Ichiro Yabe

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2569-23, (Released:2023-09-22)

参考文献数

14

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A 74-year-old man experienced diplopia, generalized muscle weakness, and acute respiratory failure. He was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) and treated with immunotherapy, but no improvement was observed, and additional symptoms, including central apnea and hallucinations, appeared. Subsequent serum and cerebrospinal fluid (CSF) analyses confirmed the presence of GABAB receptor antibodies, indicating the coexistence of autoimmune encephalitis. Although there were no findings of malignancy, it is highly likely that occult small-cell lung carcinoma was present. When atypical symptoms occur in patients with LEMS, it is important to consider the possibility of concomitant autoimmune encephalitis.