- 著者
-
Makoto Fukuda
Naoki Sawa
Daisuke Ikuma
Yuki Oba
Hiroki Mizuno
Masayuki Yamanouchi
Akinari Sekine
Eiko Hasegawa
Tatsuya Suwabe
Junichi Hoshino
Kei Kono
Keiichi Kinowaki
Kenichi Ohashi
Hiromichi Tamaki
Motoaki Miyazono
Yoshifumi Ubara
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.62, no.1, pp.81-85, 2023-01-01 (Released:2023-01-01)
- 参考文献数
- 9
- 被引用文献数
-
2
3
A 43-year-old Japanese woman with rheumatoid arthritis treated by infliximab and methotrexate for 11 years was admitted for proteinuria and purpura. A kidney biopsy revealed endothelial damage-dominant nephritis with IgA deposition. Infliximab and methotrexate were discontinued, and tocilizumab was started; however, proteinuria persisted. Therefore, tocilizumab was discontinued, and oral prednisolone and methylprednisolone pulse therapy were administered. After 6 months, urinary protein was less than 0.1 g/day, and purpura subsided. To our knowledge, this is the first case of endothelial damage-dominant nephritis related to IgA vasculitis involving the skin and kidney after long-term use of infliximab and methotrexate.