- 著者
-
Yu Mizutani
Shinichiro Kawamoto
Michiko Takahashi
Hisayo Doi
Kumiko Wakida
Satoko Tabuchi
Masaaki Tanda
Akihiro Soga
Ruri Chijiki
Hidetomo Takakura
Koji Kawaguchi
Ako Higashime
Marika Watanabe
Hiroya Ichikawa
Sakuya Matsumoto
Rina Sakai
Hideaki Goto
Keiji Kurata
Seiji Kakiuchi
Yoshiharu Miyata
Kiyoaki Uryu
Yumiko Inui
Akihito Kitao
Kimikazu Yakushijin
Hiroshi Matsuoka
Hironobu Minami
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.1314-22, (Released:2023-02-15)
- 参考文献数
- 41
- 被引用文献数
-
1
Objective High-dose chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) is an effective treatment option for relapsed and refractory aggressive malignant lymphoma. However, patients frequently experience treatment-induced gastrointestinal symptoms. Synbiotics, including live microorganisms and nondigestible food ingredients, reportedly ameliorate chemotherapy-induced mucosal damage. In this study, we assessed the efficacy and safety of synbiotics in patients undergoing auto-HSCT. Methods This randomized, double-blinded study included patients with malignant lymphoma eligible for auto-HSCT. The patients were randomly assigned to either a synbiotic group receiving Bifidobacterium longum (BB536) and guar gum or a placebo group receiving a placebo containing dextrin. The supplements were administered twice daily from the start of conditioning chemotherapy up to 28 days after auto-HSCT. The primary endpoint was the duration of total parenteral nutrition (TPN). Results In total, 12 patients were included and randomized. The median duration of TPN was 15 (range, 12-33) days in the synbiotic group and 17.5 (range, 0-32) days in the placebo group. The median duration of grade ≥3 diarrhea was shorter in the synbiotic group than in then placebo group (2.5 vs. 6.5 days), as was the duration of hospital stay (31.5 vs. 43 days). The oral intake and quality of life regarding diarrhea and anorexia improved in the synbiotic group after engraftment. Synbiotic infections, including bacteremia, were not observed. Conclusion Synbiotics may reduce gastrointestinal toxicity, thereby reducing nutritional problems and improving the quality of life of patients undergoing auto-HSCT, without severe adverse events.