著者

Kiyoshi Mabuchi Kensei Tanaka Daichi Uchijima Rina Sakai

出版者

Japanese Society of Tribologists

雑誌

Tribology Online (ISSN:18812198)

巻号頁・発行日

vol.7, no.3, pp.147-151, 2012-09-30 (Released:2012-09-30)

参考文献数

4

被引用文献数

5 12

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We measured the frictional coefficient under banana skin on floor material. Force transducer with six degrees of freedom was set under a flat panel of linoleum. Both frictional force and vertical force were simultaneously measured during a shoe sole was pushed and rubbed by a foot motion on the panel with banana skin. Measured frictional coefficient was about 0.07. This was much lower than the value on common materials and similar one on well lubricated surfaces. By the microscopic observation, it was estimated that polysaccharide follicular gel played the dominant role in lubricating effect of banana skin after the crush and the change to homogeneous sol.

著者

Yu Mizutani Shinichiro Kawamoto Michiko Takahashi Hisayo Doi Kumiko Wakida Satoko Tabuchi Masaaki Tanda Akihiro Soga Ruri Chijiki Hidetomo Takakura Koji Kawaguchi Ako Higashime Marika Watanabe Hiroya Ichikawa Sakuya Matsumoto Rina Sakai Hideaki Goto Keiji Kurata Seiji Kakiuchi Yoshiharu Miyata Kiyoaki Uryu Yumiko Inui Akihito Kitao Kimikazu Yakushijin Hiroshi Matsuoka Hironobu Minami

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.1314-22, (Released:2023-02-15)

参考文献数

41

被引用文献数

1

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Objective High-dose chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) is an effective treatment option for relapsed and refractory aggressive malignant lymphoma. However, patients frequently experience treatment-induced gastrointestinal symptoms. Synbiotics, including live microorganisms and nondigestible food ingredients, reportedly ameliorate chemotherapy-induced mucosal damage. In this study, we assessed the efficacy and safety of synbiotics in patients undergoing auto-HSCT. Methods This randomized, double-blinded study included patients with malignant lymphoma eligible for auto-HSCT. The patients were randomly assigned to either a synbiotic group receiving Bifidobacterium longum (BB536) and guar gum or a placebo group receiving a placebo containing dextrin. The supplements were administered twice daily from the start of conditioning chemotherapy up to 28 days after auto-HSCT. The primary endpoint was the duration of total parenteral nutrition (TPN). Results In total, 12 patients were included and randomized. The median duration of TPN was 15 (range, 12-33) days in the synbiotic group and 17.5 (range, 0-32) days in the placebo group. The median duration of grade ≥3 diarrhea was shorter in the synbiotic group than in then placebo group (2.5 vs. 6.5 days), as was the duration of hospital stay (31.5 vs. 43 days). The oral intake and quality of life regarding diarrhea and anorexia improved in the synbiotic group after engraftment. Synbiotic infections, including bacteremia, were not observed. Conclusion Synbiotics may reduce gastrointestinal toxicity, thereby reducing nutritional problems and improving the quality of life of patients undergoing auto-HSCT, without severe adverse events.