- 著者
- Keisuke TAKEDA Yoshito NAKAGAWA Yumi KATANO Shoichi IMAI
- 出版者
- International Heart Journal Association
- 雑誌
- Japanese Heart Journal (ISSN:00214868)
- 巻号頁・発行日
- vol.18, no.1, pp.92-101, 1977 (Released:2008-12-09)
- 参考文献数
- 10
- 被引用文献数
- 42 42
Using the isolated perfused heart preparation supported by a donor the effects of vasodilators on the large conductance artery were studied and were compared with those on the small resistive artery and arterioles. Nitroglycerin produced a preferential dilatation of the large conductance artery, while dipyridamole produced a dilatation only of the small resistive artery and arterioles.Among the "calcium antagonistic" vasodilators tested, only diltiazem produced a dilatation of the large conductance artery, verapamil and nifedipine producing a dilatation only of the samll resistive artery and arterioles. These findings indicate that the mechanism of contraction of the large conductance artery is different from that of the small resistive artery and arterioles.