- 著者
- Mio Hori Seishi Kishimoto Yu Tezuka Hideo Nishigori Keitaro Nomoto Umenoi Hamada Yoshikazu Yonei
- 出版者
- Japanese Society of Anti-Aging Medicine
- 雑誌
- ANTI-AGING MEDICINE (ISSN:18822762)
- 巻号頁・発行日
- vol.7, no.11, pp.129-142, 2010 (Released:2010-10-22)
- 参考文献数
- 43
- 被引用文献数
- 20 25
Objective: To determine the effect of beet extract on skin elasticity in female volunteers with dry skin and in human dermal fibroblasts.Method: To assess the effects of oral administration of glucosyl ceramide contained in beet extract (beet ceramide), we conducted an 8-week double-blind comparison study with 35 females (mean age: 40.9±4.2 years) with mild subjective symptoms of dry skin and declining keratin moisture levels. The compound was administered as glucosyl ceramide at 0, 0.6, or 1.8 mg/day to 3 groups (n=11, 12, 12, respectively).Results: Scores improved significantly for the following subjective skin symptoms: “concerned about dull skin,” “concerned about spots or freckles,” “sticky, oily skin,” “coarse and desiccated skin,” “not elastic, not glossy,” “concerned about rough skin,” “bags under eyes.” In addition, perspiration levels improved. The skin elasticity test (Cutometer) indicated that the elasticity index (R2 and R7) improved in a dose-dependent manner. However, we were unable to confirm the effects of ceramide on increasing skin moisture as reported in previous studies. In experiments involving human dermal fibroblasts, addition of beet ceramide promoted fibronectin synthesis and mRNA expression but had no effect on fibroblast proliferation or collagen synthesis.Conclusion: Results from clinical trials and experiments suggested that oral ingestion of beet ceramide may stimulate intracellular signals and exert favorable effects on the extracellular matrix, including the induction of fibronectin synthesis. In addition, we confirmed the safety of administering beet ceramide to humans.
- 著者
- Mari Ogura Masayuki Yagi Keitaro Nomoto Ryo Miyazaki Masaya Kongoji Show Watanabe Umenoi Hamada Yoshikazu Yonei
- 出版者
- Japanese Society of Anti-Aging Medicine
- 雑誌
- ANTI-AGING MEDICINE (ISSN:18822762)
- 巻号頁・発行日
- vol.8, no.5, pp.60-68, 2011 (Released:2011-09-17)
- 参考文献数
- 58
- 被引用文献数
- 1
Objective: Previous epidemiological surveys of diet indicated a potential relationship between fruit intake and the pathogenesis of lifestyle-related disease. Recent reports indicate grapefruit (GF) may affect sugar metabolism. The present study measured glucose, triglyceride and insulin levels in human blood after GF ingestion with and without other foods.Methods: Twelve healthy, non-smoking female volunteers, non-obese (age 40.5 ± 4.2 years old, BMI 22.0 ± 0.9) were provided with five different breakfasts on successive days: GF, bread or fried vegetables alone, GF + bread, GF + fried vegetables. In meals that included GF, the GF was eaten before the bread or fried vegetables. Blood samples were taken after meals to measure plasma glucose, immuno reactive insulin (IRI), triglyceride and vitamin C.Results: Plasma glucose following a meal of bread or fried vegetables or a meal of bread and fried vegetables with GF was similar. Insulin secretion was slower after a meal of GF alone compared to bread alone (p < 0.001) and the area under curve (AUC) of glucose per carbohydrate intake was lower when GF was eaten prior to bread or fried vegetables than after a single intake of bread or fried vegetables alone (p < 0.001). The AUC of triglyceride after a prior intake of GF before fried vegetables was slower than that after an intake of fried vegetables alone (p < 0.05). Blood vitamin C concentration increased after GF intake (p < 0.001).Conclusion: GF contains saccharides and a variety of dietary elements, including fiber, vitamins, citric acid, naringenin and bergamottin. It is possible that these compounds may affect sugar and lipid metabolism.