著者

Akane Tsuruta Tian Zheng Mari Ogura Masayuki Yagi Wakako Takabe Yoshikazu Yonei

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.6, no.1, pp.39-48, 2019 (Released:2019-05-31)

著者

Michiya Igase Yoshikazu Yonei Shigeru Matsumi Akihiko Shimode Tetsuya Maruyama Keiji Igase Maya Ohara Yoko Okada Masayuki Ochi Sayaka Matsumoto Yasumasa Ohyagi

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.6, no.2, pp.75-81, 2019 (Released:2019-07-26)

著者

Kyle Haasbroek Masayuki Yagi Yoshikazu Yonei

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.7, no.3, pp.232-239, 2020 (Released:2020-10-20)

参考文献数

64

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People with Diabetes show an increased susceptibility to infection by SARS-CoV-2, greater incidence of pneumonia, and worse clinical outcomes. As diabetes involves high glycative stress, here we present a review of the literature regarding the potential interactions of glycative stress and COVID-19 that may help to explain some of the observed differences in outcomes of diabetic patients. Glycative stress directly suppresses immune function, leaving the body less able to deal with infection. Increased colonization of potentially pathogenic bacteria, mediated by glycative stress, such as Staphylococcus aureus, may also lead to negative outcomes during infection. The presence of S. aureus on the skin may weaken its barrier function and increase the risk of infection through the skin. Proteolytic activity necessary for the virus to enter cells may be enhanced in tissue exposed to S. aureus as well as by the bacteria’s own secreted proteases. Finally, S. aureus carriage could be a risk factor for the development of secondary bacterial pneumonia during primary COVID-19 infection. In order to avoid infection and severe disease outcomes, it is important for those suspected of having diabetes to maintain strict glycemic control and take measures to avoid exposure to the virus.

著者

Mari Ogura Yuji Morita Wakako Takabe Masayuki Yagi Fuka Okuda Misato Kon Kenichi Asada Tetsuro Urata Hiroshi Yatou Hiroomi Maeda Yoshikazu Yonei

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.7, no.1, pp.29-41, 2020 (Released:2020-05-08)

参考文献数

31

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Objective: We investigated the effects of the intake of ostrich meat (OM), which is characterized by high protein and low fat, on the body, focusing on protein and amino acid metabolism and growth hormone (GH) secretion. Methods: Plasma amino acid levels, growth hormone (GH) secretion after exercise and autonomic nervous function (device used: VM500 [Fatigue Science Laboratory Inc.]) were measured in 12 healthy subjects (33.3 ± 6.9 years old, BMI 21.6 ± 1.6) after ingestion of the test food (OM) or control food for one week each. Results: A significant increase in the blood levels of branched-chain amino acids (BCAAs), lysine and histidine, and an increase in those for 1-methylhistidine and 3-methylhistidine, which are the indicators of muscle protein breakdown, were observed after the intake of OM, suggesting that protein metabolism in the muscles was activated. Subclass analysis excluding cases with high GH before exercise load showed a significant increase in GH secretion after a walking exercise (30 min) only after the intake of OM. The autonomic nervous function test did not reveal any significant findings. There were no OM-related adverse events during the study. Conclusion: OM is a low-fat meat containing physiologically significant amino acids in large quantities, and it was suggested that OM could be safe and suitable for a protein and amino acid supplement.

著者

Mio Hori Seishi Kishimoto Yu Tezuka Hideo Nishigori Keitaro Nomoto Umenoi Hamada Yoshikazu Yonei

出版者

Japanese Society of Anti-Aging Medicine

雑誌

ANTI-AGING MEDICINE (ISSN:18822762)

巻号頁・発行日

vol.7, no.11, pp.129-142, 2010 (Released:2010-10-22)

参考文献数

43

被引用文献数

20 25

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Objective: To determine the effect of beet extract on skin elasticity in female volunteers with dry skin and in human dermal fibroblasts.Method: To assess the effects of oral administration of glucosyl ceramide contained in beet extract (beet ceramide), we conducted an 8-week double-blind comparison study with 35 females (mean age: 40.9±4.2 years) with mild subjective symptoms of dry skin and declining keratin moisture levels. The compound was administered as glucosyl ceramide at 0, 0.6, or 1.8 mg/day to 3 groups (n=11, 12, 12, respectively).Results: Scores improved significantly for the following subjective skin symptoms: “concerned about dull skin,” “concerned about spots or freckles,” “sticky, oily skin,” “coarse and desiccated skin,” “not elastic, not glossy,” “concerned about rough skin,” “bags under eyes.” In addition, perspiration levels improved. The skin elasticity test (Cutometer) indicated that the elasticity index (R2 and R7) improved in a dose-dependent manner. However, we were unable to confirm the effects of ceramide on increasing skin moisture as reported in previous studies. In experiments involving human dermal fibroblasts, addition of beet ceramide promoted fibronectin synthesis and mRNA expression but had no effect on fibroblast proliferation or collagen synthesis.Conclusion: Results from clinical trials and experiments suggested that oral ingestion of beet ceramide may stimulate intracellular signals and exert favorable effects on the extracellular matrix, including the induction of fibronectin synthesis. In addition, we confirmed the safety of administering beet ceramide to humans.

著者

Yuji Morita Hiromi Izawa Atsuyuki Hirano Eriko Mayumi Seigo Isozaki Yoshikazu Yonei

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.9, no.2, pp.33-41, 2022-06-30 (Released:2022-07-17)

参考文献数

33

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Purpose: The "NAD World" (proposed by Professor Shin-Ichiro Imai of the University of Washington), in which the control of aging, lifespan, and metabolism is systemically integrated through NAD (nicotinamide adenine dinucleotide), has attracted worldwide attention and is being studied from various angles, however, there are few reports of clinical studies in humans. In this study, we investigate the changes in various biomarkers in humans after oral intake of nicotinamide mononucleotide (NMN), a precursor of NAD, and evaluate its clinical significance. Methods: Based on the approval to start the study at the ethics review, 17 postmenopausal women (mean age 55.0 years) without underlying diseases who agreed to participate in the study were subjects and received oral intake of 300 mg/day of pure NMN for eight weeks. The examination items included body measurements, basal metabolic rate, blood pressure, grip strength, glycation level (AF value), blood biochemical tests, various hormones, blood SIRT1 mRNA expression and NMN, NAD and NAM levels, immunological tests (aging, T cell subset including exhausted cells), and skin VAS (visual analog scale). Results were statistically analyzed and compared at zero and eight weeks (blood biochemistry tests were performed at four weeks to confirm safety). In addition, we asked the patients to keep a diary during the course of the study to monitor their NMN intake, their bodily sensation, and side effects. Results: One of the 17 subjects dropped out at the end of four weeks due to persistent mild headache. The results showed significant changes in NAM (nicotinamide/vitamin B3) from 45.2 to 164.7 (p < 0.001), adiponectin from 13.6 to 16.2 (p = 0.004), and skin VAS score (6/7 items, p < 0.001 to = 0.001) before and after intake. Significant differences were also observed for BMI, AF levels, platelets, HbA1c, HDL-C, amylase, DHEA-s, NAD, and narrowly defined regulatory T cells (p < 0.05 above). In addition, all subjects showed a positive bodily sensation with skin, sleep, and fatigue. There were no problems with subjective symptoms or laboratory data in the 16 who completed the study. Conclusion: NMN 300 mg/day orally for eight weeks showed no safety issues and favorable changes in many biomarkers, suggesting that NMN, a member of the NAD world, may be a promising nutritional material for aging and metabolic control in humans.

著者

Mari Ogura Masayuki Yagi Keitaro Nomoto Ryo Miyazaki Masaya Kongoji Show Watanabe Umenoi Hamada Yoshikazu Yonei

出版者

Japanese Society of Anti-Aging Medicine

雑誌

ANTI-AGING MEDICINE (ISSN:18822762)

巻号頁・発行日

vol.8, no.5, pp.60-68, 2011 (Released:2011-09-17)

参考文献数

58

被引用文献数

1

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Objective: Previous epidemiological surveys of diet indicated a potential relationship between fruit intake and the pathogenesis of lifestyle-related disease. Recent reports indicate grapefruit (GF) may affect sugar metabolism. The present study measured glucose, triglyceride and insulin levels in human blood after GF ingestion with and without other foods.Methods: Twelve healthy, non-smoking female volunteers, non-obese (age 40.5 ± 4.2 years old, BMI 22.0 ± 0.9) were provided with five different breakfasts on successive days: GF, bread or fried vegetables alone, GF + bread, GF + fried vegetables. In meals that included GF, the GF was eaten before the bread or fried vegetables. Blood samples were taken after meals to measure plasma glucose, immuno reactive insulin (IRI), triglyceride and vitamin C.Results: Plasma glucose following a meal of bread or fried vegetables or a meal of bread and fried vegetables with GF was similar. Insulin secretion was slower after a meal of GF alone compared to bread alone (p < 0.001) and the area under curve (AUC) of glucose per carbohydrate intake was lower when GF was eaten prior to bread or fried vegetables than after a single intake of bread or fried vegetables alone (p < 0.001). The AUC of triglyceride after a prior intake of GF before fried vegetables was slower than that after an intake of fried vegetables alone (p < 0.05). Blood vitamin C concentration increased after GF intake (p < 0.001).Conclusion: GF contains saccharides and a variety of dietary elements, including fiber, vitamins, citric acid, naringenin and bergamottin. It is possible that these compounds may affect sugar and lipid metabolism.