- 著者
- Masahiro Kawahara Ken-ichiro Tanaka Midori Kato-Negishi
- 出版者
- Japan Society for Biomedical Research on Trace Elements
- 雑誌
- Metallomics Research (ISSN:24365173)
- 巻号頁・発行日
- vol.1, no.1, pp.rev-47-rev-65, 2021-12-15 (Released:2022-01-29)
- 参考文献数
- 176
Aluminum (Al) is the third most abundant element in the earth’s crust. However, because of its specific chemical properties, Al is not essential for life, and it exerts various adverse effects on plants, animals, and humans. In particular, Al is a widely recognized neurotoxin. The association between Al and neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis and Parkinson’s disease dementia in the Kii Peninsula and Guam has been suspected. However, controversy has persisted for several decades. Based on recent epidemiological, analytical, and toxicological studies, we review the detailed characteristics of Al neurotoxicity and revisit its link to Alzheimer’s disease and other diseases. The daily intake of Al and its bioavailability linked with adverse effects on human health are also described.
1 0 0 0 OA Long-term Efficacy and Safety of Sitagliptin in Elderly Patients with Type 2 Diabetes Mellitus
- 著者
- Yuko Tada Ippei Kanazawa Masakazu Notsu Ken-ichiro Tanaka Nobuaki Kiyohara Motofumi Sasaki Toshitsugu Sugimoto
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.55, no.10, pp.1275-1278, 2016 (Released:2016-05-15)
- 参考文献数
- 16
- 被引用文献数
- 1 4
Objective We herein conducted a retrospective study to evaluate the long-term efficacy and safety of sitagliptin treatment in elderly patients with type 2 diabetes mellitus. Methods We analyzed the changes in glycemic control in 112 Japanese type 2 diabetes patients over 65 years of age treated with 50 mg/day sitagliptin. Hemoglobin A1c (HbA1c) levels, liver and kidney functions, and usage of hypoglycemic agents were recorded for 24 months. Results HbA1c levels were significantly decreased, and the significance of HbA1c reduction was maintained during the observation period [from 7.7±1.1% to 7.2±0.7% (p Conclusion Sitagliptin treatment continually decreases the HbA1c level for 24 months and is useful to reduce the dose of sulfonylurea in elderly patients with type 2 diabetes.