著者

Yuji ITO Kenji FUJIMOTO

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E105-A, no.1, pp.1-10, 2022-01-01

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Recently, control theory using machine learning, which is useful for the control of unknown systems, has attracted significant attention. This study focuses on such a topic with optimal control problems for unknown nonlinear systems. Because optimal controllers are designed based on mathematical models of the systems, it is challenging to obtain models with insufficient knowledge of the systems. Kernel functions are promising for developing data-driven models with limited knowledge. However, the complex forms of such kernel-based models make it difficult to design the optimal controllers. The design corresponds to solving Hamilton-Jacobi (HJ) equations because their solutions provide optimal controllers. Therefore, the aim of this study is to derive certain kernel-based models for which the HJ equations are solved in an exact sense, which is an extended version of the authors' former work. The HJ equations are decomposed into tractable algebraic matrix equations and nonlinear functions. Solving the matrix equations enables us to obtain the optimal controllers of the model. A numerical simulation demonstrates that kernel-based models and controllers are successfully developed.

著者

Koki Ibayashi Yoshihisa Fujino Masakazu Mimaki Kenji Fujimoto Shinya Matsuda Yu-ichi Goto

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.2, pp.68-75, 2023-02-05 (Released:2023-02-05)

参考文献数

33

被引用文献数

3

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Background: To provide a better healthcare system for patients with mitochondrial diseases, it is important to understand the basic epidemiology of these conditions, including the number of patients affected. However, little information about them has appeared in Japan to date.Methods: To gather data of patients with mitochondrial diseases, we estimated the number of patients with mitochondrial diseases from April 2018 through March 2019 using a national Japanese health care claims database, the National Database (NDB). Further, we calculated the prevalence of patients, and sex ratio, age class, and geographical distribution.Results: From April 2018 through March 2019, the number of patients with mitochondrial diseases was 3,629, and the prevalence was 2.9 (95% confidence interval [CI], 2.8–3.0) per 100,000 general population. The ratio of females and males was 53 to 47, and the most frequent age class was 40–49 years old. Tokyo had the greatest number of patients with mitochondrial diseases, at 477, whereas Yamanashi had the fewest, at 13. Kagoshima had the highest prevalence of patients with mitochondrial diseases, 8.4 (95% CI, 7.1–10.0) per 100,000 population, whereas Yamanashi had the lowest, 1.6 (95% CI, 0.8–2.7).Conclusion: The number of patients with mitochondrial diseases estimated by this study, 3,269, was more than double that indicated by the Japanese government. This result may imply that about half of all patients are overlooked for reasons such as low severity of illness, suggesting that the Japanese healthcare system needs to provide additional support for these patients.

著者

Keiji Muramatsu Hanaka Imamura Kei Tokutsu Kenji Fujimoto Kiyohide Fushimi Shinya Matsuda

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.4, pp.163-167, 2022-04-05 (Released:2022-04-05)

参考文献数

25

被引用文献数

4 9

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Background: Food allergies are common among children, and food-induced anaphylaxis (FIA) is a serious disease with a risk of death; however, there is yet to be a large-scale epidemiological study on causative foods in Japan. The purpose of this study was to identify foods that cause FIA in Japan.Methods: We identified 9,079 patients from the Japanese Diagnosis Procedure Combination Database who were admitted for treatment for FIA from April 1, 2014 through March 31, 2017. We extracted data on patient sex, age, use of epinephrine injections on the first day, prescription for epinephrine self-injection on the day of discharge, length of stay, readmission, and causative foods.Results: The most common causative food was eggs, followed by wheat, milk, peanuts, and buckwheat. The most common causative food in each age group was eggs among 0–3-year-olds, milk among 4–6-year-olds, peanuts among 7–19-year-olds, and wheat among those aged 20 years and older. Epinephrine was used at admission among about 40%, 50%, and over 60% of cases in which the causative food was eggs; wheat, milk and peanuts; and buckwheat, respectively. The proportion of cases with a prescription for epinephrine self-injection at discharge was highest among those in which the causative food was wheat, followed by peanuts, buckwheat, milk, and eggs.Conclusions: FIA due to peanuts has become as common in Japan as it is in the West. These results suggest the importance of taking measures to prevent peanut allergies because children cannot make adequate decisions regarding food.