- 著者
- Kenroh Sasaki Fumihiko Yoshizaki
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.25, no.6, pp.806-808, 2002 (Released:2002-06-01)
- 参考文献数
- 18
- 被引用文献数
- 28 32
A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3′,4′,5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 μM) exhibited more potency than Kojic acid (IC50; 77.4 μM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.