著者

Vladisavljević Goran T. Khalid Nauman Neves Marcos A. Kuroiwa Takashi Nakajima Mitsutoshi Uemura Kunihiko Ichikawa Sosaku Kobayashi Isao

出版者

Elsevier B.V.

雑誌

Advanced drug delivery reviews (ISSN:0169409X)

巻号頁・発行日

vol.65, no.11-12, pp.1626-1663, 2013-11

被引用文献数

246 9

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Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.