著者

Koichi Shishido

出版者

The Medical Society of Kansai Medical University

雑誌

関西医科大学雑誌 (ISSN:00228400)

巻号頁・発行日

vol.26, no.Supplement, pp.S1-S13, 1974-03-20 (Released:2013-02-19)

参考文献数

20

被引用文献数

1 1

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The proportion of dietary protein modifies the tumorgenesis of glandular stomach in rats that received NG in drinking water. If a 50% casein diet is given regularly from the date of carcinogenic stimulus by NG, the final tumor number and their malignancy are more pronounced than in other groups maintained on 20% or 36% casein diets.36% casein diets, when given concurrently with the carcinogen throughout the experimental period, showed slightly more accelerated tumorgenesis than rats on 20% casein diets, but there were about the same number of malignancies. The survival time of rats on 5 % casein diets was too short and no tumors developed among rats that survived 5 to 6 monthes after experimental initiation.The general conclusion drawn from these data is that high dietary protein exerts a potentiation effect on NG tumorgenesis, especially in carcinogenesis.