- 著者
- Shoko Tomooka Emi Oishi Masako Asada Satoko Sakata Jun Hata Sanmei Chen Takanori Honda Kosuke Suzuki Hiroshi Watanabe Norihito Murayama Naohisa Wada Takanari Kitazono Toshiharu Ninomiya
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- pp.JE20220232, (Released:2022-12-24)
- 参考文献数
- 37
- 被引用文献数
- 1
Background: The association between chronic lipopolysaccharide exposure and the development of metabolic syndrome (MetS) is unclear. In this study we examined the association between serum lipopolysaccharide-binding protein (LBP) levels, an indicator of lipopolysaccharide exposure, and the development of MetS in a general Japanese population.Methods: 1,869 community-dwelling Japanese individuals aged ≥40 years without MetS at baseline examination in 2002–2003 were followed up by repeated examination in 2007–2008. MetS was defined according to the Japanese criteria. Serum LBP levels were classified into quartiles (quartiles 1–4: 2.20–9.56, 9.57–10.78, 10.79–12.18, and 12.19–24.34 μg/mL, respectively). Odds ratios (ORs) for developing MetS were calculated using a logistic regression model.Results: At the follow-up survey, 159 participants had developed MetS. Higher serum LBP levels were associated with greater risk of developing MetS after multivariable adjustment for age, sex, smoking, drinking, and exercise habits (OR [95% confidence interval] for quartiles 1–4: 1.00 [reference], 2.92 [1.59–5.37], 3.48 [1.91–6.35], and 3.86 [2.12–7.03], respectively; P for trend <0.001). After additional adjustment for homeostasis model assessment of insulin resistance, this association was attenuated but remained significant (P for trend=0.007). On the other hand, no significant association was observed after additional adjustment for serum high-sensitivity C-reactive protein (P for trend=0.07).Conclusions: In the general Japanese population, our findings suggest that higher serum LBP levels are associated with elevated risk of developing MetS. Low-grade endotoxemia could play a role in the development of MetS through systemic chronic inflammation and insulin resistance.
- 著者
- Shoko Tomooka Emi Oishi Masako Asada Satoko Sakata Jun Hata Sanmei Chen Takanori Honda Kosuke Suzuki Hiroshi Watanabe Norihito Murayama Naohisa Wada Takanari Kitazono Toshiharu Ninomiya
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- vol.34, no.1, pp.1-7, 2024-01-05 (Released:2024-01-05)
- 参考文献数
- 37
- 被引用文献数
- 1
Background: The association between chronic lipopolysaccharide exposure and the development of metabolic syndrome (MetS) is unclear. In this study we examined the association between serum lipopolysaccharide-binding protein (LBP) levels, an indicator of lipopolysaccharide exposure, and the development of MetS in a general Japanese population.Methods: 1,869 community-dwelling Japanese individuals aged ≥40 years without MetS at baseline examination in 2002–2003 were followed up by repeated examination in 2007–2008. MetS was defined according to the Japanese criteria. Serum LBP levels were classified into quartiles (quartiles 1–4: 2.20–9.56, 9.57–10.78, 10.79–12.18, and 12.19–24.34 µg/mL, respectively). Odds ratios (ORs) for developing MetS were calculated using a logistic regression model.Results: At the follow-up survey, 159 participants had developed MetS. Higher serum LBP levels were associated with greater risk of developing MetS after multivariable adjustment for age, sex, smoking, drinking, and exercise habits (OR [95% confidence interval] for quartiles 1–4: 1.00 [reference], 2.92 [1.59–5.37], 3.48 [1.91–6.35], and 3.86 [2.12–7.03], respectively; P for trend <0.001). After additional adjustment for homeostasis model assessment of insulin resistance, this association was attenuated but remained significant (P for trend = 0.007). On the other hand, no significant association was observed after additional adjustment for serum high-sensitivity C-reactive protein (P for trend = 0.07).Conclusion: In the general Japanese population, our findings suggest that higher serum LBP levels are associated with elevated risk of developing MetS. Low-grade endotoxemia could play a role in the development of MetS through systemic chronic inflammation and insulin resistance.
- 著者
- Kosuke SUZUKI Masaya KOUJI Masato YOSHINO
- 出版者
- The Japan Society of Mechanical Engineers
- 雑誌
- Journal of Fluid Science and Technology (ISSN:18805558)
- 巻号頁・発行日
- vol.18, no.1, pp.JFST0011, 2023 (Released:2023-04-26)
- 参考文献数
- 24
We conducted measurements of a butterfly’s motion in forward flight and numerical simulations using a computational model reflecting its motion. We measured the motion of a cabbage white butterfly (Pieris rapae), and then we constructed a computational model composed of a thorax, an abdomen, and four wings (i.e., left and right wings with fore and hind parts). Furthermore, we calculated the flow field and aerodynamic force and torque generated by the butterfly model using the immersed boundary–lattice Boltzmann method. In this simulation, we considered two types of periodic motions corresponding to slightly-descending and ascending forward flights. As a result, we found that the wing-tip and leading-edge vortices are formed on the wings and then released backward and downward in both flights. The major difference between the two flights is the flapping amplitude, indicating that the butterfly changes the flapping amplitude for each period and increases it to ascend. In addition, we considered a chimera model whose motion is based on the slightly-descending flight but partly given by the ascending flight. As a result, we found that the pitching angle and the angle of attack determine the traveling direction, but simply changing these angles does not achieve the ascending flight due to insufficient lift force. Thus, the butterfly should adjust the flapping and lead–lag angles in response to the pitching angle and the angle of attack to change the flight mode.