- 著者
- Keimei Oh Kouta Nakai Kazuhiro Yamada Yuko Yoshizawa
- 出版者
- 日本農薬学会
- 雑誌
- Journal of Pesticide Science (ISSN:1348589X)
- 巻号頁・発行日
- vol.37, no.1, pp.80-84, 2012-03-20 (Released:2012-02-20)
- 参考文献数
- 21
- 被引用文献数
- 4 8
A series of new triazole derivatives was synthesized and their inhibitory activity against allene oxide synthase (AOS, CYP74A), a key enzyme in jasmonic acid biosynthesis, was evaluated. Structure-activity relationship studies revealed that methyl 8-[1-(naphthalen-2-yl)-2-(1,2,4-triazol-1-yl)ethoxy]octanate (4i) and methyl 8-[1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)ethoxy]octanate (4g) exhibit potent inhibitory activity to allene oxide synthase, with IC50 values of 0.75±0.30 and 0.84±0.60 μM, respectively.