- 著者
- Panita Pathipvanich Naho Tsuchiya Archawin Rojanawiwat Wolf-Peter Schmidt Wattana Auwanit Pathom Sawanpanyalert Koya Ariyoshi
- 出版者
- 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- 雑誌
- Japanese Journal of Infectious Diseases (ISSN:13446304)
- 巻号頁・発行日
- vol.66, no.5, pp.375-378, 2013 (Released:2013-09-19)
- 参考文献数
- 14
- 被引用文献数
- 3 5
We conducted a hospital-based descriptive study to describe the changing pattern of patient numbers, characteristics, and mortality rates among human immunodeficiency virus (HIV)-infected patients in northern Thailand over 15 years. The survival status on October 31, 2010 of all HIV-infected adults who attended an HIV center in a government hospital between 1995 and 2010 was ascertained. In total, 3,706 patients were registered, 2,118 (57.2%) of which were male. The survival status of 3,439 patients (92.9%) was available. In addition, 1,543 deaths were identified out of 12,858 person-year-observations (PYO) resulting in a mortality rate of 12.4 deaths/100 PYO (95% confidence interval [CI], 11.3–13.0). An initial decline in mortality rates was observed prior to 1999, probably because of an increase in the proportion of less symptomatic patients. After the introduction of the national highly active antiretroviral therapy (HAART) program, a profound decline in mortality rates was observed, reaching 2.0 deaths/100 PYO (95% CI, 1.4–2.9) in 2010. Simultaneously, the number of patients on follow-up increased by nearly fourfold. Although HAART has drastically improved the survival of HIV-infected patients, the number of patients receiving therapy at this HIV clinic has substantially increased. While referral of HIV patients to general physicians' care should be urged, we cannot overemphasize the importance of preventing new HIV infections.
- 著者
- Hung Thai Do Dong Thanh Nguyen Lan Anh Thi Nguyen Duong Huy Do Huy Xuan Le Xuan Mai Thi Trinh Hong Vy Nu Ton Ikumi Sawada Noriko Kitamura Nhat Minh Le Keisuke Yoshihara Thu Huong Thi Phan Chien Trong Bui Koya Ariyoshi Lay Myint Yoshida
- 出版者
- 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- 雑誌
- Japanese Journal of Infectious Diseases (ISSN:13446304)
- 巻号頁・発行日
- pp.JJID.2016.512, (Released:2017-09-11)
- 参考文献数
- 24
- 被引用文献数
- 7
We investigated the prevalence of HIV drug resistance among high risk groups such as injecting drug user (IDU), female sex worker (FSW) and men having sex with men (MSM) in central Vietnam. We used HIV positive samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays and the positive samples were further tested for HIV viral load and drug resistant mutations by in-house assays. Drug resistant mutations (DRMs) were determined using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 subjects were screened and 97 were positive (IDU: N=63, 3%, FSW: N=24, 0.8% and MSM: N=10, 1%). Ninety-two samples (45 from 2012 and 47 from 2013) were available for further testing. HIV viral load was detected in 56 (60.9%) samples and drug resistant genotyping was successfully performed in 40 (71.4%) samples. All were CRF01_AE, except for one (2.5%) IDU with subtype B. Thirteen individuals (32.5%) were carrying HIV virus with at least one HIV DRM: 9 IDUs, 1 FSW and 3 MSM. The HIV seroprevalence among high risk individuals in central Vietnam was low however high proportion of drug resistant HIV-1 was observed in high risk group.