3 0 0 0 OA 戦前日本における家計調査の特質
- 著者
- 齋藤 邦明 サイトウ クニアキ Kuniaki Saito
- 雑誌
- 立教經濟學研究
- 巻号頁・発行日
- vol.69, no.2, pp.205-227, 2015-10
1 0 0 0 OA Antibody testing for COVID-19 in patients with acute coronary syndrome in Aichi Prefecture
- 著者
- Masataka Yoshinaga Takashi Muramatsu Hidetsugu Fujigaki Kuniaki Saito Hideo Izawa
- 出版者
- Fujita Medical Society
- 雑誌
- Fujita Medical Journal (ISSN:21897247)
- 巻号頁・発行日
- pp.2020-032, (Released:2021-08-20)
- 参考文献数
- 4
1 0 0 0 IR 戦前日本における家計調査の特質 (菊地進教授記念号)
- 著者
- 齋藤 邦明 サイトウ クニアキ Kuniaki Saito
- 出版者
- 立教大学経済学研究会
- 雑誌
- 立教経済学研究 (ISSN:00355356)
- 巻号頁・発行日
- vol.69, no.2, pp.205-227, 2015-10
1 0 0 0 OA The epigenetic regulation of transposable elements by PIWI-interacting RNAs in Drosophila
- 著者
- Kuniaki Saito
- 出版者
- The Genetics Society of Japan
- 雑誌
- Genes & Genetic Systems (ISSN:13417568)
- 巻号頁・発行日
- vol.88, no.1, pp.9-17, 2013 (Released:2013-05-14)
- 参考文献数
- 76
- 被引用文献数
- 8 28
A mechanism is required to repress the expression and transposition of transposable elements (TEs) to ensure the stable inheritance of genomic information. Accumulating evidence indicates that small non-coding RNAs are important regulators of TEs. Among small non-coding RNAs, PIWI-interacting RNAs (piRNAs) serve as guide molecules for recognizing and silencing numerous TEs and work in collaboration with PIWI subfamily proteins in gonadal cells. Disruption of the piRNA pathway correlates with loss of proper genomic organization, gene expression control and fertility. Moreover, recent studies on the molecular mechanisms of piRNA biogenesis and on piRNA function have shown that piRNAs act as maternally inherited genic elements, transferring information about repressed TEs to progeny. These findings enable a molecular explanation of mysterious epigenetic phenomena, such as hybrid dysgenesis and TE adaptation with age. Here, I review our current knowledge of piRNAs derived from biochemical and genetic studies and discuss how small RNAs are utilized to maintain genome organization and to provide non-DNA genetic information. I mainly focus on Drosophila but also discuss comparisons with other species.