2 0 0 0 OA Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs
- 著者
- Lee-Shuan LIN Yuko KAYASUGA Nobuyuki SHIMOHATA Hiroyuki KAMATA Shigeki SUZUKI Ryosuke ECHIGO Manabu MOCHIZUKI Ung-Il CHUNG Nobuo SASAKI
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.12-0109, (Released:2012-06-20)
- 被引用文献数
- 2 2 1
Trehalose has several novel anti-inflammatory and cell-protective functions. We hypothesized that lyophilized aspirin/trehalose could decrease the severity of aspirin-induced gastropathy. Thirteen dogs were assigned into aspirin, lyophilized aspirin/trehalose, and control groups, and the gastric lesions were assessed on gastroscopy with the modified Lanza scale. Another 6 dogs were used to measure the plasma aspirin concentration by high-performance liquid chromatography after aspirin or lyophilized aspirin/trehalose administration. The results indicated that lyophilized aspirin/trehalose induced less gastric ulceration than aspirin despite maintaining therapeutic concentrations of plasma aspirin in both the groups. Lyophilized aspirin/trehalose might be a solution to decrease aspirin-induced gastropathy.
1 0 0 0 OA Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs
- 著者
- Lee-Shuan LIN Yuko KAYASUGA Nobuyuki SHIMOHATA Hiroyuki KAMATA Shigeki SUZUKI Ryosuke ECHIGO Manabu MOCHIZUKI Ung-Il CHUNG Nobuo SASAKI
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.74, no.11, pp.1511-1516, 2012 (Released:2012-12-01)
- 参考文献数
- 41
- 被引用文献数
- 2 2
Trehalose has several novel anti-inflammatory and cell-protective functions. We hypothesized that lyophilized aspirin/trehalose could decrease the severity of aspirin-induced gastropathy. Thirteen dogs were assigned into aspirin, lyophilized aspirin/trehalose, and control groups, and the gastric lesions were assessed on gastroscopy with the modified Lanza scale. Another 6 dogs were used to measure the plasma aspirin concentration by high-performance liquid chromatography after aspirin or lyophilized aspirin/trehalose administration. The results indicated that lyophilized aspirin/trehalose induced less gastric ulceration than aspirin despite maintaining therapeutic concentrations of plasma aspirin in both the groups. Lyophilized aspirin/trehalose might be a solution to decrease aspirin-induced gastropathy.