著者

Lijuan Liu Yanbin Liu Weijun Tong Hong Ye Xianyu Zhang Wuchun Cao Yonghong Zhang

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.71, no.11, pp.1761-1764, 2007 (Released:2007-10-25)

参考文献数

27

被引用文献数

22 26

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Background Associations between pathogens and hypertension (HT) has been reported, but few studies have focused on the relationship between aggregate pathogens and HT. The present study explored whether the risk of HT is associated with each pathogen (defined as Chlamydia pneumoniae (C. pneumoniaee), Mycoplasma pneumoniae (M. pneumoniae), Helicobacter pylori (H. pylori) and Coxsackie virus) or with aggregate pathogens in Chinese Mongolians. Methods and Results One thousand and thirty Chinese Mongolians aged 30 years or more were recruited, including 488 hypertensive and 942 normotensive subjects. Enzyme-linked immunosorbent assay was used to detect IgG antibodies for C. pneumoniaee, M. pneumoniae, H. pylori and Coxsackie virus. The seroprevalence of Coxsackie virus was significantly associated with HT (odds ratio (OR) 3.7 after adjustment for risk factors), but no significant association was found for C. pneumoniae, M. pneumoniae and H. pylori (OR 1.32, 0.75 and 1.19, respectively). The results also showed that the risk of HT was associated with the aggregate pathogens: it increased with the increasing number of pathogens, and the ORs were 1.629, 2.653, 2.129, and 5.146 for 1, 2, 3 and 4 pathogens, respectively, after controlling for risk factors. Conclusion The risk of HT is associated with Coxsackie virus and aggregate pathogen load. The mechanism(s) underlying the associations remain to be elucidated further. (Circ J 2007; 71: 1761 - 1764)

著者

Nan ZHAO Donghu ZHEN Zhiyun ZHAO Songbo FU Conghui GUAN Lijuan LIU Xulei TANG

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.1, pp.8-15, 2022-02-28 (Released:2022-02-28)

参考文献数

31

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This study aims to examine whether low serum 25-hydroxyvitamin D [25(OH)D] concentrations are correlated with increased risk of incident type 2 diabetes (T2D) in a Chinese population. The present prospective cohort study included 5,543 participants aged 40–75 y old and is free of diabetes at baseline in Lanzhou city, China. Serum 25(OH)D concentrations were measured. T2D incidence was defined based on obtained results from oral glucose tolerance tests or a self-reported previous diagnosis of diabetes by healthcare professionals. The association between baseline serum 25(OH)D concentrations and incident T2D was investigated using Cox proportional hazards model and restricted cubic spline. Of 5,543 participants (1,433 men and 4,110 women) followed for an average period of 3.9 y, 239 (4.3%) developed diabetes. No significant difference in serum 25(OH)D concentrations was found between individuals who developed diabetes and those who did not (p>0.05). Furthermore, serum 25(OH)D quartiles were not associated with T2D incidence (HR 1.33, 95% CI: 0.89–1.97, p=0.18) after adjusting for body mass index (BMI) and other potential confounders, as well as in subgroups classified with sex (men, women), glucose status (normal glucose tolerance, prediabetes), and BMI (<25 kg/m2, ≥25 kg/m2). The lower serum 25(OH)D concentrations are not associated to a higher risk of incident T2D in the present Chinese cohort after adjusting for BMI and other numerous potential confounding factors.