著者

Yuichiro Jin Daiki Yaegashi Lin Shi Mari Ishida Chiemi Sakai Tetsuro Yokokawa Yu Abe Akira Sakai Takayoshi Yamaki Hiroyuki Kunii Kazuhiko Nakazato Naoko Hijioka Kazuo Awai Satoshi Tashiro Yasuchika Takeishi Takafumi Ishida

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.63, no.3, pp.466-475, 2022-05-30 (Released:2022-05-31)

参考文献数

34

被引用文献数

1

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Almost 40% of medical radiation exposure is related to cardiac imaging or intervention. However, the biological effects of low-dose radiation from medical imaging remain largely unknown. This study aimed to evaluate the effects of ionized radiation from cardiac catheterization on genomic DNA integrity and inflammatory cytokines in patients and operators.Peripheral mononuclear cells (MNCs) were isolated from patients (n = 51) and operators (n = 35) before and after coronary angiography and/or percutaneous coronary intervention. The expression of γH2AX, a marker for DNA double-strand breaks, was measured by immunofluorescence. Dicentric chromosomes (DICs), a form of chromosome aberrations, were assayed using a fluorescent in situ hybridization technique.In the patient MNCs, the numbers of γH2AX foci and DICs increased after cardiac catheterization by 4.5 ± 9.4-fold and 71 ± 122%, respectively (P < 0.05 for both). The mRNA expressions of interleukin (IL)-1α, IL-1β, leukemia inhibitory factor, and caspase-1 were significantly increased by radiation exposure from cardiac catheterization. The increase in IL-1β was significantly correlated with that of γH2AX, but not with the dose area product. In the operators, neither γH2AX foci nor the DIC level was changed, but IL-1β mRNA was significantly increased. The protein expression of IκBα was significantly decreased in both groups.DNA damage was increased in the MNCs of patients, but not of operators, who underwent cardiac catheterization. Inflammatory cytokines were increased in both the patients and operators, presumably through NF-κB activation. Further efforts to reduce radiation exposure from cardiac catheterization are necessary for both patients and operators.

著者

石 林 Lin Shi

出版者

中京大学大学院経営学研究科

雑誌

中京経営紀要 = Journal of the Graduate School of Business Administration (ISSN:13463985)

巻号頁・発行日

no.6, pp.31-42, 2006-02

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変化が激しい経営環境に取り巻かれる現代企業にとって、知識はすでにヒト・モノ・カネに次いで第四の経営資源となっている。企業のコア・コンピタンスを常に向上し、持続的な競争優位を確保するため、知識資源を大切に扱わなければならない。その背景の中で「ナレッジマネジメント」と呼ばれる研究領域が1990年代に発足し、現在は数多くの分野に展開されている。知識資源の創造、共有、活用により組織の経営成果を向上することがナレッジマネジメントの目的であるが、従来のナレッジマネジメント研究では、抽象的な理論や研究モデルをいかに仕事現場に噛み砕いて企業の実務に関連付けるかという課題が深刻に存在している。本稿では、上述の課題に注目し、従来のナレッジマネジメント理論研究のレビューを行い、ナレッジマネジメントの全体像を捉える上で、実践的フレームワークの提案を試みる。