著者

Fei Li Rong Tang Ling-Bo Chen Ke-Sheng Zhang Xiao-Ping Huang Chang-Qing Deng

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.40, no.5, pp.598-609, 2017-05-01 (Released:2017-05-01)

参考文献数

27

被引用文献数

20

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Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg−1), Angelica (3.00 g·kg−1), and combinations of Astragalus and Angelica at different ratios, including 10 : 1 (Astragalus 9.81 g·kg−1+Angelica 0.98 g·kg−1), 5 : 1 (Astragalus 9.00 g·kg−1+Angelica 1.80 g·kg−1), 2 : 1 (Astragalus 7.71 g·kg−1+Angelica 3.08 g·kg−1), 1 : 1 (Astragalus 5.40 g·kg−1+Angelica 5.40 g·kg−1), 1 : 2.5 (Astragalus 3.08 g·kg−1+Angelica 7.71 g·kg−1), 1 : 5 (Astragalus 1.80 g·kg−1+Angelica 9.00 g·kg−1), and 1 : 10 (Astragalus 0.98 g·kg−1+Angelica 9.81 g·kg−1). Our results suggested that Astragalus mixed with Angelica synergistically promoted hematopoiesis best when the combination ratio of Astragalus and Angelica was 1 : 1, 1 : 2.5 or 1 : 5; moreover, the effect of Angelica was greater than that of Astragalus. The potential mechanisms of the combinations of Astragalus and Angelica that promote hematopoiesis include the dissolution of the effective components, promoting the synthesis and secretion of hematopoietic growth factor (HGF) and the proliferation of hematopoietic progenitor cells (HPCs).