- 著者
- Kana Kikegawa Kyuuichirou Takamatsu Masaru Kawakami Hidemitsu Furukawa Hiroyuki Mayama Yoshimune Nonomura
- 出版者
- 公益社団法人 日本油化学会
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.66, no.4, pp.383-389, 2017 (Released:2017-04-03)
- 参考文献数
- 32
- 被引用文献数
- 2
Hierarchical structures, also known as fractal structures, exhibit advantageous material properties, such as water- and oil-repellency as well as other useful optical characteristics, owing to its self-similarity. Various methods have been developed for producing hierarchical geometrical structures. Recently, fractal structures have been manufactured using a 3D printing technique that involves computer-aided design data. In this study, we confirmed the accuracy of geometrical structures when Koch curve-like fractal structures with zero to three generations were printed using a 3D printer. The fractal dimension was analyzed using a box-counting method. This analysis indicated that the fractal dimension of the third generation hierarchical structure was approximately the same as that of the ideal Koch curve. These findings demonstrate that the design and production of fractal structures can be controlled using a 3D printer. Although the interior angle deviated from the ideal value, the side length could be precisely controlled.
- 著者
- IKUO ADACHI TERUO YAMAMORI YOSHIHARU HIRAMATSU KATSUNORI SAKAI SHIN-ICHI MIHARA MASARU KAWAKAMI MASAO MASUI OSAMU UNO MOTOHIKO UEDA
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.36, no.11, pp.4389-4402, 1988-11-25 (Released:2011-02-08)
- 参考文献数
- 19
- 被引用文献数
- 31 49
A series of 4-aryl-4, 7-dihydrothieno [2, 3-b] pyridine-5-carboxylate derivatives (I) was synthesized and tested for binding affinity to Ca2+ channels in rat cerebral cortex membranes, coronary vasodilator effect in isolated guinea pig hearts, and antihypertensive activity in spontaneously hypertensive rats.Several compounds had potent coronary vasodilator and antihypertensive activities.The structure-ctivity relationships of the series indicated that a lipophilic 3-alkyl substituent with moderate bulkiness was effective for enhancing the pharmacological potencies.Among them, methyl 4, 7-dihydro-3-isobuty1-6-methy1-4-(3-nitrophenyl) thieno [2, 3-b] pyridine-5-carboxylate (S-312) was selected as a promising cardiovascular agent.The relationship between the absolute configuration of S-312 and its biological activities is also presented.
- 著者
- Masato TAKANOKURA Tetsuo Yamada Masaru Kawakami Seiko Taki Munenori KAKEHI
- 出版者
- ISCM Forum
- 雑誌
- Innovation and Supply Chain Management (ISSN:21870969)
- 巻号頁・発行日
- vol.10, no.2, pp.71-77, 2016-06-30 (Released:2016-12-21)
- 参考文献数
- 12
- 被引用文献数
- 2
A healthcare service was visualized by physical activity of healthcare workers ’tasks at a longterm care nursing home in Japan. Physical activity was measured by four healthcare workers using an activity meter. The workers ’tasks in healthcare services were quanti?ed by high-intensity activity of 3.0 METs (metabolic equivalents) or more, and by the relationship between physical activity and healthcare tasks. A higher workload for healthcare workers could be quanti?ed by the average physical activity and the cumulative time of high-intensity activity of 3.0 METs or more. Healthcare workers with signi?cant experience completed daily tasks effectively, but the tasks included high-intensity physical activity or a higher workload. In addition to observational methods, improvement of healthcare services should be considered by quantitative variables.