- 著者
- TOSHIAKI HAYASHI TAKAO NOTO YOSHIHARU NAWATA HIROSHI OKAZAKI MIKIO SAWADA KUNIO ANDO
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.35, no.7, pp.771-777, 1982 (Released:2006-04-12)
- 参考文献数
- 17
- 被引用文献数
- 16 25
A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad spectrum antimicrobial and antitumor activity.
1 0 0 0 OA HYPOLIPIDEMIC PROPERTY OF ASCOFURANONE
- 著者
- MIKIO SAWADA TOMOYOSHI HOSOKAWA TSUNEO OKUTOMI KUNIO ANDO
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.26, no.11, pp.681-686, 1973-11-25 (Released:2006-04-12)
- 参考文献数
- 15
- 被引用文献数
- 24 28
Ascofuranone significantly reduced serum lipid levels of rats fed with normal diet 6 hours after a single oral administration of 108 mg/kg. When the antibiotic was orally given for consecutive 10 days to normolipidemic rats, the treatment resulted in marked reduction of serum cholesterol, triglycerides, phospholipids and free fatty acids without affecting organ weight gain, serum total protein, albumin/globulin ratio and serum transaminases. Reduction was also noted with cardiac cholesterol content but liver total sterol and fecal sterol excretion were unchanged. Acute toxicity of ascofuranone is weak to mice and rats and the antibiotic did not induce hepatomegaly which is the main side effect of a positive control agent, ethyl-p-chlorophenoxyisobutyrate.
1 0 0 0 OA ISOLATION AND STRUCTURE OF ASCOFURANONE AND ASCOFRANOL, ANTIBIOTICS WITH HYPOLIPIDEMIC ACTIVITY
- 著者
- HIROSHI SASAKI TOMOYOSHI HOSOKAWA MIKIO SAWADA KUNIO ANDO
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.26, no.11, pp.676-680, 1973-11-25 (Released:2006-04-12)
- 参考文献数
- 15
- 被引用文献数
- 43 68
A new antibiotic with hypolipidemic activity, ascofuranone, C23H29C1O5, and related substance, ascofuranol, C23H31C1O5, were isolated from the filter cake of the fermented broth of Ascochyta viciae LIBERT, an ascochlorin-producing fungus, and their structures were elucidated. They possess 3-substituted-5-chloro-orcylaldehyde moiety with novel sesquiterpenyl side chains.