- 著者
- MITSUAKI MAEDA MINEO SANEYOSHI YUTAKA KAWAZOE
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.19, no.8, pp.1641-1649, 1971-08-25 (Released:2011-02-08)
- 参考文献数
- 28
- 被引用文献数
- 14 19
The reaction mechanism for the hydrogen exchange of C-8 hydrogens of purine ribosides was discussed on the basis of the pD-rate profiles and the effect of 6-substituents on the rate. It was shown that the rate depended on concentrations of the purine and D2O and that the observed second-order rate constant was expressed as kOD-KD2O/Ka (N7) where kOD-was the rate constant for hydrogen exchange of N7-protonated purines by attack with the OD-, KD2O was the dissociation constant of D2O, and Ka (N7) was the dissociation constant of N7-protonated purines.
- 著者
- Mitsuaki MAEDA Noriko A. UCHIDA Takuma SASAKI
- 出版者
- The Japanese Cancer Association
- 雑誌
- Japanese Journal of Cancer Research GANN (ISSN:09105050)
- 巻号頁・発行日
- vol.77, no.6, pp.523-525, 1986 (Released:2008-03-17)
- 参考文献数
- 5
- 被引用文献数
- 3
Seventeen liposoluble bis (carboxylato)-cyclohexane-1, 2-diammineplatinum (II) and bis (carboxylato)-cis-diammineplatinum(II) complexes were synthesized and tested for antitumor activity against leukemia L1210 cells in mice. The former complexes had excellent antitumor activity without any toxicity to the host at the therapeutic dose when used with lipiodol as a carrier solvent. The latter complexes had neither antitumor activity nor toxicity in vivo. The former complexes were gradually released from lipiodol to saline in vitro; the latter were not. The activity depended on the chain length of the carboxylato residue and also on the molecular shape of the ligand part of the complexes.