著者
MITSUAKI MAEDA MINEO SANEYOSHI YUTAKA KAWAZOE
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.19, no.8, pp.1641-1649, 1971-08-25 (Released:2011-02-08)
参考文献数
28
被引用文献数
14 19

The reaction mechanism for the hydrogen exchange of C-8 hydrogens of purine ribosides was discussed on the basis of the pD-rate profiles and the effect of 6-substituents on the rate. It was shown that the rate depended on concentrations of the purine and D2O and that the observed second-order rate constant was expressed as kOD-KD2O/Ka (N7) where kOD-was the rate constant for hydrogen exchange of N7-protonated purines by attack with the OD-, KD2O was the dissociation constant of D2O, and Ka (N7) was the dissociation constant of N7-protonated purines.