著者

Manabu Okumura Kiyoaki Shirai Kanako Komiya Hikaru Yokono

出版者

The Association for Natural Language Processing

雑誌

自然言語処理 (ISSN:13407619)

巻号頁・発行日

vol.18, no.3, pp.293-307, 2011 (Released:2011-10-04)

参考文献数

12

被引用文献数

4 4

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An overview of the SemEval-2 Japanese WSD task is presented. The new characteristics of our task are (1) the task will use the first balanced Japanese sense-tagged corpus, and (2) the task will take into account not only the instances that have a sense in the given set but also the instances that have a sense that cannot be found in the set. It is a lexical sample task, and word senses are defined according to a Japanese dictionary, the Iwanami Kokugo Jiten. This dictionary and a training corpus were distributed to participants. The number of target words was 50, with 22 nouns, 23 verbs, and 5 adjectives. Fifty instances of each target word were provided, consisting of a total of 2,500 instances for the evaluation. Nine systems from four organizations participated in the task.

著者

奥村 学 Manabu Okumura 東京工業大学精密工学研究所 Precision and Intelligence Laboratory Tokyo Institute of Technology

出版者

人工知能学会

雑誌

人工知能学会誌 = Journal of Japanese Society for Artificial Intelligence (ISSN:09128085)

巻号頁・発行日

vol.21, no.4, pp.424-429, 2006-07-01

参考文献数

15

被引用文献数

6

著者

Yohei Kawano Masashi Nagata Takafumi Kohno Akihiro Ichimiya Tomomi Iwakiri Manabu Okumura Kazuhiko Arimori

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.3, pp.400-407, 2012-03-01 (Released:2012-03-01)

参考文献数

40

被引用文献数

17 19 7

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Caffeine is thought to increase the antitumor effect of cisplatin or DNA-damaging agents because it is known that caffeine inhibits DNA repair. Caffeine-assisted chemotherapy has been used in the treatment of osteosarcomas. In addition, there are several reports about combination chemotherapy with caffeine for certain malignancies other than osteosarcomas. However, there are no reports that show the utility of combination chemotherapy with caffeine for hepatocellular carcinoma (HCC). We examined the combined effects of caffeine and cisplatin in human HCC cell lines, and screened for a more effective administration method of caffeine in vitro. Human HCC cell lines (HepG2, HLF, HuH-7, and Li-7) were exposed to caffeine (0—0.5 mM) and cisplatin (0—1.2 μg/mL) for 72 h, either alone or in combination. Cell numbers were measured by WST-8 assay, and cell apoptosis was determined by annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) binding assay. As a result, caffeine increased the antitumor effect of cisplatin on cell proliferation and cell apoptosis in the HCC cell lines. Moreover, this effect was dependent on the amount of exposure to caffeine. These results suggest that caffeine-assisted chemotherapy is useful for HCC treatment.