著者

Hiroki Uehara Masaki Okuyama Yutaro Oe Takaki Yoshimura Takahiro Gunji

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0436, (Released:2023-08-30)

参考文献数

1

著者

Hiroki Uehara Masaki Okuyama Yutaro Oe Takaki Yoshimura Takahiro Gunji

出版者

The Editorial Committee of Annals of Vascular Diseases

雑誌

Annals of Vascular Diseases (ISSN:1881641X)

巻号頁・発行日

pp.cr.23-00024, (Released:2023-06-22)

参考文献数

8

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A 65-year-old Japanese man without medical history presented with sudden onset lower abdominal pain to our emergency department. Contrast-enhanced computed tomography (CT) revealed dissections of the inferior mesenteric artery and left renal artery with false lumen thrombosis without aortic dissection. He was immediately hospitalized, and conservative treatment was administered. However, on the third-day post-onset, the patient reported severe upper abdominal pain and contrast-enhanced CT showed a new superior mesenteric artery dissection. He continued to receive conservative treatment, and his symptoms improved. He was discharged after ten days of hospitalization.

著者

Minako Yamaoka Seiji Yamaguchi Masaki Okuyama Hitonobu Tomoike

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.63, no.12, pp.951-956, 1999 (Released:2001-08-25)

参考文献数

41

被引用文献数

45 46

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Proinflammatory cytokines, ie, tumor necrosis factor-alpha (TNFα), participate in the development and the progression of congestive heart failure (CHF). On the other hand, an anti-inflammatory cytokine may neutralize the proinflammatory cytokines of CHF. Interleukin-10 (IL-10) is known to suppress the synthesis of proinflammatory cytokines. IL-10 and the IL-10 receptor system was investigated in comparison with the behavior of TNF α in 68 patients with various causes of CHF (mean age: 61 years) and in 31 normal subjects (61 years). The circulating IL-10 level was higher in CHF patients than in normal subjects (p<0.05). The TNFα level was higher in CHF patients than in control subjects (p<0.005). The ratio of IL-10 to TNFα tended to be higher in control subjects than in patients with CHF (p=0.09). With lipopolysaccharide treatment, the release of IL-10 was more enhanced from mononuclear leukocyte of patients with CHF than from control subjects (p<0.05). The expression of the IL-10 receptor estimated by flow cytometry of mononuclear leukocytes was higher in the CHF patients than in the normal subjects. The IL-10/IL-10 receptor system was activated, at least partly, to downregulate an excess of TNF α in patients with advanced CHF. IL-10 may be an important inherent component of the cytokine network of CHF. (Jpn Circ J 1999; 63: 951 - 956)