- 著者
- Masamitsu Tsukamoto Hiroshi Kikugawa Souichiro Nagayama Taketo Suganuma Tatsuya Okita Hidenori Miyamoto
- 出版者
- Pesticide Science Society of Japan
- 雑誌
- Journal of Pesticide Science (ISSN:1348589X)
- 巻号頁・発行日
- vol.46, no.2, pp.152-159, 2021-05-20 (Released:2021-05-25)
- 参考文献数
- 21
- 被引用文献数
- 7
Tolpyralate, a new selective postemergence herbicide developed for the weed control in corn, possesses a unique chemical structure with a 1-alkoxyethyl methyl carbonate group on the N-ethyl pyrazole moiety. This compound shows high herbicidal activity against many weed species, including glyphosate-resistant Amaranthus tuberculatus. Tolpyralate targets 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), which is involved in the tyrosine degradation pathway. Inhibition of the enzyme destroys the chlorophyll, thereby killing the susceptible weeds. Details of tolpyralate discovery, structure optimization, and biological activities are described.