著者

Sadahiko Yamazaki Kunihide Hoshino Masatoshi Kusuhara

出版者

Japanese Society of Anti-Aging Medicine

雑誌

ANTI-AGING MEDICINE (ISSN:18822762)

巻号頁・発行日

vol.7, no.6, pp.60-65, 2010 (Released:2010-05-22)

参考文献数

21

被引用文献数

30 42

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Human body odor is generated by waste materials present on the skin surface and secretions from the sweat and sebaceous glands. These waste materials are converted to characteristic odorous compounds through oxidative degradation or metabolism by skin microbes. Changes in body odor due to aging relate to the amount and composition of sweat and sebum secreted, as well as gland activity. 2-Nonenal has an unpleasant, greasy, grassy odor and is mainly detected in people aged over 40 years. Generation of 2-nonenal is related to oxidative degradation of ω7 unsaturated fatty acids. Given that body odor may function as a barometer indicating the body's overall health, further understanding of this odor's makeup is important. Here, we define several types of body odor and describe changes in body odor, with a specific focus on 2-nonenal, an odor characteristically associated with aging.

著者

Ken YAMAGUCHI Kenichi URAKAMI Takeshi NAGASHIMA Yuji SHIMODA Shumpei OHNAMI Sumiko OHNAMI Keiichi OHSHIMA Tohru MOCHIZUKI Keiichi HATAKEYAMA Masakuni SERIZAWA Yasuto AKIYAMA Kouji MARUYAMA Hirohisa KATAGIRI Yuji ISHIDA Kaoru TAKAHASHI Seiichiro NISHIMURA Masanori TERASHIMA Taiichi KAWAMURA Yusuke KINUGASA Yushi YAMAKAWA Tetsuro ONITSUKA Yasuhisa OHDE Takashi SUGINO Ichiro ITO Hiroyuki MATSUBAYASHI Yasue HORIUCHI Maki MIZUGUCHI Mutsumi YAMAZAKI Kengo INOUE Kimiko WAKAMATSU Misato SUGIYAMA Katsuhiko UESAKA Masatoshi KUSUHARA

出版者

バイオメディカルリサーチプレス

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.37, no.4, pp.259-264, 2016-08-01 (Released:2016-08-20)

参考文献数

25

被引用文献数

7

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Using whole exome sequencing data obtained from 1,685 Japanese cancer patients, we examined genetic variations of germline TP53 and found 10 types of non-synonymous single nucleotide variants. In the present study, we focused on 6 patients with germline D49H mutation located in the transactivation domain 2 of p53 protein, since the mutation seemed to be prevalent in cancer patients and to be pathogenic. According to the initial survey for family history of the proband with the germline TP53 D49H mutation, one osteosarcoma patient and his pedigree fulfill the criteria for Li-Fraumeni-like syndrome and the 2009 Chompret criteria for germline TP53 mutation screening. Since this patient possesses double germline mutations of TP53 D49H and A159D, further studies are required to evaluate contribution of the D49H mutation in this morbidity. The remaining 5 patients had family histories of cancer, but none fulfills the criteria either for the Li-Fraumeni/Li-Fraumeni-like syndromes or the 2009 Chompret criteria for germline TP53 mutation screening. It is possible to postulate that the germline TP53 D49H mutation is likely to be low-penetrant in some pedigrees. The present study also indicates that the survey for the germline TP53 mutation plays an important role in clinical practice as it will prevent mistaking cancer patients with unusual heredities for sporadic cases.