著者

Shuichi CHIBA Masatoshi SUZUKI Keitaro YAMANOUCHI Masugi NISHIHARA

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

vol.53, no.2, pp.297-307, 2007 (Released:2007-05-12)

参考文献数

54

被引用文献数

43 54

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Recent studies have demonstrated the presence of neurogenesis in the adult mammalian hippocampus, and it has been suggested that estrogen and various growth factors influence the processes of adult neurogenesis. The present study assessed cell proliferation in the dentate gyrus and the mRNA expression levels of granulin, insulin-like growth factor-I (IGF-I), and brain-derived neurotrophic factor (BDNF) in the hippocampus 4 h after treatment with estradiol benzoate (EB) in 3- and 12-month old ovariectomized rats. At 3 months of age, mRNA expression of granulin precursor and cell proliferation were increased by EB treatment, although the mRNA expressions of IGF-I and BDNF remained unchanged. At 12 months of age, however, neither mRNA expression of the three genes nor cell proliferation in the dentate gyrus were affected by EB treatment. In addition, 17β-estradiol enhanced the proliferation of neural progenitor cells derived from hippocampal tissue of 3-month-old female rats in vitro; this was inhibited by neutralization of granulin with specific antibody. These results suggest that estrogen induces granulin gene expression in the hippocampus and that the product of this gene is involved in the mitogenic effects of estrogen in the dentate gyrus, although the responses to estrogen decline with age.

著者

Hidenori Yamaguchi Masatoshi Suzuki Mami Nakamura Rika Okamura Ayako Tsuji Takahiro Sasaki Koh Shibutani

出版者

Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo

雑誌

International Journal of Oral-Medical Sciences (ISSN:13479733)

巻号頁・発行日

vol.19, no.2, pp.88-98, 2020-10-01 (Released:2020-10-02)

参考文献数

36

被引用文献数

1