- 著者
- Ghazi Mohamed Eisa Hussein Hisashi Matsuda Seikou Nakamura Makoto Hamao Toshihito Akiyama Kouhei Tamura Masayuki Yoshikawa
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.34, no.12, pp.1849-1855, 2011-12-01 (Released:2011-12-01)
- 参考文献数
- 26
- 被引用文献数
- 39 52
We previously investigated the effects of an aqueous extract of maté (mate) tea, made from the leaves of Ilex paraguariensis, on the diabesity and metabolic syndrome features in a mouse model. Mate induced significant decreases in body weight (BW), body mass index, and food intake (FI). In this study, to verify the mode of action of mate on FI and consequently on BW, we examined the anorexic effects of mate on the appetite and satiety markers glucagon-like peptide 1 (GLP-1) and leptin in high-fat diet-fed ddY mice. GLP-1 is a peptide signal generated by the gastrointestinal tract, which regulates appetite and influences BW, whereas leptin is an afferent signal from the periphery to the brain in a homeostatic feedback loop that regulates adipose tissue mass, thus leading to decreased appetite and FI and increased energy expenditure. Chronic administration of mate (50, 100 mg/kg) for 3 weeks significantly reduced FI, BW, and ameliorated blood fats, liver fats, and adipose tissue. Mate induced significant increases in GLP-1 levels and leptin levels compared with the control. Acute administration of major constituents of mate showed significant increases in GLP-1 levels by dicaffeoyl quinic acids and matesaponins, and significant induction of satiety by caffeoyl quinic acids and caffeine in ddY mice. These findings suggest that mate may induce anorexic effects by direct induction of satiety and by stimulation of GLP-1 secretion and modulation of serum leptin levels.
- 著者
- Toshio Morikawa Hideo Oominami Hisashi Matsuda Masayuki Yoshikawa
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.58, no.11, pp.1541-1544, 2010-11-01 (Released:2010-11-01)
- 参考文献数
- 37
- 被引用文献数
- 12 20
Four new ursane-type triterpenes, olibanumols K (1), L (2), M (3), and N (4), were isolated from traditional Egyptian medicine olibanum, the exuded gum-resin from Boswellia carterii BIRDW. Their structures were elucidated on the basis of chemical and physicochemical evidence.
- 著者
- Naoki ITO Daisuke KUWAHARA Yoshio NAGAYAMA Masayuki YOSHIKAWA Junko KOHAGURA Shoji SUGITO Atsushi MASE Yuichiro KOGI Tomokazu YOSHINAGA Soichiro YAMAGUCHI
- 出版者
- The Japan Society of Plasma Science and Nuclear Fusion Research
- 雑誌
- Plasma and Fusion Research (ISSN:18806821)
- 巻号頁・発行日
- vol.10, pp.3402034-3402034, 2015-04-16 (Released:2017-01-23)
- 参考文献数
- 10
- 被引用文献数
- 4
Microwave to millimeter-wave diagnostics techniques, such as interferometry, reflectometry, scattering, and radiometry, have been powerful tools for diagnosing magnetically confined plasmas. The resultant measurements have clarified several physics issues, including instability, wave phenomena, and fluctuation-induced transport. Electron cyclotron emission imaging has been an important tool in the investigation of temperature fluctuations, while reflectometry has been employed to measure plasma density profiles and their fluctuations. We have developed a horn-antenna mixer array (HMA), a 50 - 110 GHz 1D antenna array, which can be easily stacked as a 2D array. This article describes an upgrade to the horn mixer array that combines well-characterized mixers, waveguide-to-microstrip line transitions, intermediate frequency amplifiers, and internal local oscillator modules using a monolithic microwave integrated circuit technology to improve system performance. We also report on the use of a multi-channel HMA system.
- 著者
- Jiang Liu Seikou Nakamura Yan Zhuang Masayuki Yoshikawa Ghazi Mohamed Eisa Hussein Kyohei Matsuo Hisashi Matsuda
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.61, no.6, pp.655-661, 2013-06-01 (Released:2013-06-01)
- 参考文献数
- 50
- 被引用文献数
- 7 22
Six dihydroisocoumarin glycosides, florahydrosides I and II, thunberginol G 8-O-β-d-glucopyranoside, thunberginol C 8-O-β-d-glucopyranoside, 4-hydroxythunberginol G 3′-O-β-d-glucopyranoside, and thunberginol D 3′-O-β-d-glucopyranoside, have been isolated from the flowers of Hydrangea macrophylla Seringe var. thunbergii Makino (Saxifragaceae) together with 20 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, acylated quinic acid analog, neochlorogenic acid, was shown to substantially inhibit aldose reductase [IC50=5.6 µm]. In addition, the inhibitory effects on aldose reductase of several caffeoylquinic acid analogs were examined for structure–activity relationship study. As the results, 4,5-O-trans-p-dicaffeoyl-d-quinic acid was found to exhibit a potent inhibitory effect [IC50=0.29 µm].