- 著者
-
Mayumi Tsuji
Chihaya Koriyama
Yasuhiro Ishihara
Megumi Yamamoto
Kiwako Yamamoto-Hanada
Kumiko Kanatani
Yu Ait Bamai
Kazunari Onishi
Ayako Senju
Shunsuke Araki
Eiji Shibata
Seiichi Morokuma
Masafumi Sanefuji
Hiroshi Kitazawa
Mayako Saito
Masakazu Umezawa
Atsuto Onoda
Koichi Kusuhara
Rie Tanaka
Toshihiro Kawamoto
the Japan Environment & Children’s Study Group
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- pp.JE20180098, (Released:2019-01-12)
- 参考文献数
- 54
- 被引用文献数
-
7
Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.