著者

Thi Hong Van Le Gwang Jin Lee Huynh Kim Long Vu Sung Won Kwon Ngoc Khoi Nguyen Jeong Hill Park Minh Duc Nguyen

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.63, no.11, pp.950-954, 2015-11-01 (Released:2015-11-01)

参考文献数

20

被引用文献数

22

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Chemical and pharmacological studies of Panax vietnamensis (Vietnamese ginseng; VG) have been reported since its discovery in 1973. However, the content of each saponin in different parts of VG has not been reported. In this study, 17 ginsenosides in the different underground parts of P. vietnamensis were analyzed by HPLC/evaporative light scattering detector (ELSD). Their contents in the dried rhizome, radix, and fine roots were 195, 156, and 139 mg/g, respectively, which were extremely high compared to other Panax species. The content of protopanaxatriol (PPT)-type saponins were not much different among underground parts; however, the content of protopanaxadiol (PPD)- and ocotillol (OCT)-type saponins were greatly different. It is noteworthy that the ginsenoside pattern in the fine roots is different from other underground parts. In particular, despite the content of PPD-type saponins being the highest in the fine roots, which is similar to other Panax species, the total content of saponins was the lowest in the fine roots, which is different from other Panax species. The ratios of PPT : PPD : OCT-type saponins were 1 : 1.7 : 7.8, 1 : 1.6 : 5.5, and 1 : 4.8 : 3.3 for the rhizome, radix, and fine roots, respectively. OCT-type saponins accounted for 36–75% of total saponins and contributed mostly to the difference in the total saponin content of each part.

著者

MINH DUC Nguyen THOI NHAM Nguyen 笠井 良次 伊藤 優子 山崎 和男 田中 治

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.11, pp.2010-2014, 1993-11-15

被引用文献数

6

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From rhizomes and roots of Panax vietnamensis HA et GRUSHV., Araliaceae, commonly known as Vietnamese Ginseng, two new acetylated saponins named vina-ginsenoside-R1 (13) and vina-ginsenoside-R2 (15) were isolated. On the basis of chemical and spectral data, 13 was formulated as monoacetyl 24(S)-pseudo-ginsenoside-F_<11> and 15 was proved to be monoacetyl majonoside-R2.Besides the two new saponins and β-sitosteryl-3-O-β-D-glucopyranoside, sixteen known saponins were also isolated and identified. Dammarane saponins : ginsenoside-Rh_1 and 20(R)-ginsenoside-Rh_1 (1), ginsenosides-Rg_1 (2), -Re (3), -Rd(6), -Rb_3 (7), -Rb_2 (8), -Rb_1 (9), pseudo-ginsenoside-RS_1 (=monoacetyl ginsenoside-Re, 4), notoginsenosides-R1 (5) and -Fa (10). Ocotillol-type saponins : pseudo-ginsenoside-RT_4 (11), 24(S)-pseudo-ginsenoside-F_<11> (12), majonosides-R1 (16) and -R2 (14). Oleanolic acid saponins : ginsenoside-Ro (=chikusetsusaponin V, 17) and hemsloside-Ma3 (18), a saponin previously isolated from a cucurbitaceous plant, Hemsleya macrosperma C. Y. WU.Despite having large horizontally elongated rhizomes, the underground part of this plant contains mainly dammarane saponins and a small amount of oleanolic acid saponins. In addition, the yield of ocotillol-type saponins, especially majonoside-R2,is surprisingly very high (more than 5% and ca. half of the total yield of saponin). This characteristic saponin composition has made Vietnamese Ginseng an interesting species among Panax spp.