著者

神田 博史 徳本 和佳子 坂本 季代恵 藤井 美智子 平井 裕子 山崎 和男 菰田 泰夫 中村 英雄 石原 茂正 内田 勝

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.33, no.4, pp.1367-1374, 1985-04-25

被引用文献数

12

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The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. From the physiologically active fraction of the extract, along with the known triterpenes ganoderic acids A and B, two new triterpenes were isolated and named ganoderic acids C and D. The structures of ganoderic acids C and D were determined to be 3β, 7β, 15α-trihydroxy-11,23-dioxo-5α-lanost-8-en-26-oic acid and 7β-hydroxy-3,11,15,23-tetraoxo-5α-lanost-8-en-26-oic acid respectively. Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. Quantitative analysis of these triterpenes was performed for the purpose of crude drug quality control.

著者

MINH DUC Nguyen THOI NHAM Nguyen 笠井 良次 伊藤 優子 山崎 和男 田中 治

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.11, pp.2010-2014, 1993-11-15

被引用文献数

6

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From rhizomes and roots of Panax vietnamensis HA et GRUSHV., Araliaceae, commonly known as Vietnamese Ginseng, two new acetylated saponins named vina-ginsenoside-R1 (13) and vina-ginsenoside-R2 (15) were isolated. On the basis of chemical and spectral data, 13 was formulated as monoacetyl 24(S)-pseudo-ginsenoside-F_<11> and 15 was proved to be monoacetyl majonoside-R2.Besides the two new saponins and β-sitosteryl-3-O-β-D-glucopyranoside, sixteen known saponins were also isolated and identified. Dammarane saponins : ginsenoside-Rh_1 and 20(R)-ginsenoside-Rh_1 (1), ginsenosides-Rg_1 (2), -Re (3), -Rd(6), -Rb_3 (7), -Rb_2 (8), -Rb_1 (9), pseudo-ginsenoside-RS_1 (=monoacetyl ginsenoside-Re, 4), notoginsenosides-R1 (5) and -Fa (10). Ocotillol-type saponins : pseudo-ginsenoside-RT_4 (11), 24(S)-pseudo-ginsenoside-F_<11> (12), majonosides-R1 (16) and -R2 (14). Oleanolic acid saponins : ginsenoside-Ro (=chikusetsusaponin V, 17) and hemsloside-Ma3 (18), a saponin previously isolated from a cucurbitaceous plant, Hemsleya macrosperma C. Y. WU.Despite having large horizontally elongated rhizomes, the underground part of this plant contains mainly dammarane saponins and a small amount of oleanolic acid saponins. In addition, the yield of ocotillol-type saponins, especially majonoside-R2,is surprisingly very high (more than 5% and ca. half of the total yield of saponin). This characteristic saponin composition has made Vietnamese Ginseng an interesting species among Panax spp.