- 著者
- Hiroyuki OKADA Kohtaro MIYAZAWA Shigeo FUKUDA Yoshifumi IWAMARU Morikazu IMAMURA Kentaro MASUJIN Yuichi MATSUURA Takashi FUJII Kei FUJII Soichi KAGEYAMA Miyako YOSHIOKA Yuichi MURAYAMA Takashi YOKOYAMA
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.13-0363, (Released:2013-08-27)
- 被引用文献数
- 3 9
The aim of this study was to investigate the presence of disease-associated prion protein (PrPSc) in the skeletal muscle of cattle infected with classical bovine spongiform encephalopathy (C-BSE). The study was carried out systematically in 12 different muscle samples from 43 (3 field and 40 experimental) cases of C-BSE; however, muscle spindles were not available in many of these cases. Therefore, analysis became restricted to a total of 31 muscles in 23 cattle. Even after this restriction, low levels of PrPSc were detected in the muscle spindles of the masseter, intercostal, triceps brachii, psoas major, quadriceps femoris and semitendinosus muscles from 3 field and 6 experimental clinical-stage cases. The present data indicate that small amounts of PrPSc are detectable by immunohistochemistry in the skeletal muscles of animals terminally affected with C-BSE.
- 著者
- Nobuaki SHIMADA Hideo MURATA Osamu MIKAMI Miyako YOSHIOKA Keerthi S. GURUGE Noriko YAMANAKA Yasuyuki NAKAJIMA Shigeru MIYAZAKI
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.68, no.10, pp.1113-1115, 2006 (Released:2006-11-05)
- 参考文献数
- 12
- 被引用文献数
- 10 12
Genetically modified corn Bt11 is insect-resistant and expresses Cry1Ab toxin, an insecticidal protein, in kernels. Although Bt11 corn is considered safe based on animal performance, there are no reports available on the clinico-biochemical effects of feeding it to cattle. In this study, we evaluated the effects of feeding Bt11 to calves, using blood and ruminal clinico-biochemical parameters. Our three-month-long feeding experiment demonstrated that calves (n=6), fed with a ration containing 43.3% of Bt11 corn kernels as dry matter, did not develop any discernible clinical, hematological, biochemical, or ruminal abnormalities as compared with control calves (n=6) fed non-Bt11 corn. The results suggest that the transgenic Bt11 has no negative clinico-biochemical effects on calves.