- 著者
- Yuta SHINOHARA Yoko NISHINO Megumi YAMANAKA Keitaro OHMORI Mohamed ELBADAWY Tatsuya USUI Kazuaki SASAKI
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.19-0401, (Released:2019-10-22)
- 被引用文献数
- 3
Vincristine, one of the anti-cancer drugs used in veterinary practice, has adverse hematological and gastrointestinal effects in dogs. Juzen-taiho-to is a traditional Chinese medicine used for patients with anorexia in human medicine. However, the protective effects of Juzen-taiho-to against anti-cancer drug-induced toxicity in dogs have not been investigated. We therefore examined whether the administration of Juzen-taiho-to to dogs affects gastric motility, and vincristine-induced gastrointestinal and hematological toxicity. The study was composed of three trials. In the first trial, Juzen-taiho-to (450 mg/kg/day) was orally administered to five dogs. In the second and third trials, vincristine (0.75 mg/m2) was intravenously administered to each dog in the absence or presence of Juzen-taiho-to (450 mg/kg/day). During these trials, gastric motility and blood parameters were assessed. Juzen-taiho-to increased gastric motility and improved vincristine-induced gastrointestinal, but not hematological, adverse effects in dogs. This study suggested that Juzen-taiho-to may be applicable for gastrointestinal care in dogs receiving chemotherapy.
- 著者
- Toshinori Yoshida Mio Kobayashi Suzuka Uomoto Kanami Ohshima Emika Hara Yoshitaka Katoh Naofumi Takahashi Takanori Harada Tatsuya Usui Mohamed Elbadawy Makoto Shibutani
- 出版者
- JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
- 雑誌
- Journal of Toxicologic Pathology (ISSN:09149198)
- 巻号頁・発行日
- vol.35, no.3, pp.225-235, 2022 (Released:2022-07-02)
- 参考文献数
- 66
- 被引用文献数
- 4
The development of in vitro toxicity assessment methods using cultured cells has gained popularity for promoting animal welfare in animal experiments. Herein, we briefly discuss the current status of hepatoxicity assessment using human- and rat-derived hepatocytes; we focus on the liver organoid method, which has been extensively studied in recent years, and discuss how toxicologic pathologists can use their knowledge and experience to contribute to the development of in vitro chemical hepatotoxicity assessment methods for drugs, pesticides, and chemicals. We also propose how toxicological pathologists should assess toxicity regarding the putative distribution of undifferentiated and differentiated cells in the organoid when liver organoids are observed in hematoxylin and eosin–stained specimens. This was done while considering the usefulness and limitations of in vitro studies for toxicologic pathology assessment.