著者

Masafumi YAO Kyosuke YAMAMOTO Takashi KIMURA Munehiko DOMBO

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.14, no.6, pp.589, 2008 (Released:2009-02-18)

参考文献数

26

被引用文献数

9 11

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The anti-rhinitis properties of Sparassis crispa were investigated in mice. To examine the immunomodulative activity of oral administration of S. crispa, splenocytes obtained from ovalbumin-sensitized BALB/c mice fed S. crispa were restimulated in vitro with the same antigen. Oral administration of S. crispa induced IFN-γ, but inhibited IL-4 and IL-5 secretion, and suppressed ovalbumin-specific IgE secretion by ovalbumin-stimulated splenocytes. The effects of S. crispa were further investigated by using the allergic rhinitis model in BALB/c mice. Nasal symptoms, sneezing and nasal rubbing induced by ovalbumin challenges were inhibited by oral administration of S. crispa in a dose-dependent manner. Furthermore, ovalbumin-specific serum IgE levels were diminished in this model. These results demonstrated that S. crispa may be effective in suppressing symptoms of allergic rhinitis through its immunomodulating activities.