- 著者
- Ami Fukunaga Yosuke Inoue Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Makoto Yamamoto Toshiaki Miyamoto Takeshi Kochi Masafumi Eguchi Naoki Gommori Kenya Yamamoto Ai Hori Maki Konishi Nobumi Katayama Isamu Kabe Seitaro Dohi Tetsuya Mizoue
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- pp.JE20220245, (Released:2023-03-11)
- 参考文献数
- 23
Background: Diabetes and prediabetes have been linked with morbidity or mortality from cardiovascular disease, cancer, or other physical disorders among working-age populations, but less is known about outcomes directly related to labor loss (e.g., long-term sickness absence (LTSA) or pre-retirement death due to physical disorders).This prospective study aimed to examine the association of diabetes and prediabetes with the risk of a composite outcome of LTSA and pre-retirement death due to physical disorders. The present study also examined the associations of severe outcomes (LTSA or death) due to specific physical disorders or injuries/external causes in relation to diabetes and prediabetes.Methods: Data were derived from the Japan Epidemiology Collaboration on Occupational Health study. A total of 60,519 workers from 12 companies were followed for eight years. Diabetes and prediabetes were defined based on the American Diabetes Association criteria. A Cox proportional hazards regression model was used to examine the association between diabetes/prediabetes and severe outcomes due to physical disorders or injuries/external causes.Results: The adjusted hazard ratios (95% confidence intervals) of severe outcomes due to all physical disorders were 1.22 (1.02–1.45) and 2.32 (2.04–2.64) for prediabetes and diabetes, respectively. In cause-specific analyses, an increased risk was observed for severe outcomes due to cancers, cardiovascular diseases, diseases of the musculoskeletal system, and injuries/external causes in relation to either or both diabetes and prediabetes.Conclusions: Diabetes and prediabetes were associated with an increased risk of severe outcomes due to physical disorders or injuries/external causes among Japanese workers.