- 著者
- Naohito NISHII Rie OKADA Moeka MATSUBA Satoshi TAKASHIMA Yui KOBATAKE Hitoshi KITAGAWA
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.19-0169, (Released:2019-06-14)
- 被引用文献数
- 10
The aim of the current study was to identify independent risk factors for thyroid axis alterations in dogs with non-thyroidal diseases. In this retrospective cross-sectional study, data and plasma samples from 207 dogs with non-thyroidal diseases was used. The involvement of various factors (disease severity, sex, age, breed, category and duration of disease, and medication) in the alteration of plasma thyroxine (T4) or thyroid-stimulation hormone (TSH) concentrations was analyzed using multivariate logistic regression. Among the 207 dogs analyzed, 99 (47.8%) had low plasma T4 concentrations, while 45 (21.7%) had high TSH concentrations. Intact male sex [odds ratio (OR), 3.25; 1.67–6.35; P<0.001], Labrador Retrievers (OR, 18.70; 2.32–151.00; P=0.006), moderate (OR, 2.39; 1.21–4.74; P=0.012) and severe diseases (OR, 6.84; 2.27–20.70; P<0.001) were associated with increased risk for low plasma T4 concentrations. Meanwhile, intact male (OR, 3.93; 1.51–10.30; P=0.005), spayed female (OR, 4.22; 1.59–11.20; P=0.004), older age (OR, 2.73; 1.28–5.84; P=0.009), and Miniature Dachshunds (OR, 5.39; 2.38–12.20; P<0.001) had increased risk for high plasma TSH concentrations.Disease severity had been determined as an independent risk factor for canine NTIS. In addition, sex, age and breed were also associated with thyroid axis alterations in dogs with non-thyroidal diseases.