著者

Chayanont BHAMARASUTA Kanyavee PREMRATANACHAI Nitchanan MONGKOLPINYOPAT Pamila YOTHAPAND Thitapa VEJPATTARASIRI Thasinas DISSAYABUTRA Monkon TRISIRIROJ Saikaew SUTAYATRAM Chollada BURANAKARL

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0574, (Released:2021-02-09)

被引用文献数

1

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Iron metabolism, hepcidin and some blood profiles were investigated in 13 healthy and 31 chronic kidney disease (CKD) dogs. The study consisted of 2 experiments, experiment I included healthy dogs (CONT) and CKD dogs (stage 2, 3 and 4), while experiment II consisted of anemic CKD dogs subjected to 28-day darbepoetin alfa treatment. The response to darbepoetin alfa could divide anemic CKD dogs into responder (RP) and non-responder (NRP) subgroups. The results from experiment I showed that packed cell volume (PCV) and plasma albumin concentration were significantly lower in CKD dogs of all stages while the total iron binding capacity (TIBC) was lower in only CKD stage 3 and 4 compared with dogs in CONT group. The PCV was related to both TIBC and albumin when considering among all dogs or only in CKD dogs. The hepcidin concentration in CKD dogs with anemia was lower than those without anemia (P<0.05). In experiment II before darbepoetin alfa treatment, RP subgroup had significantly higher iron and TIBC compared with NRP subgroup (P<0.05), the iron concentration was decreased only in RP subgroup after darbepoetin alfa treatment (P<0.05). The percent increase in PCV was correlated with initial TIBC (P<0.01). Plasma hepcidin concentration was not different between CONT and CKD groups and between RP and NRP subgroups both before and after darbepoetin alfa treatment. It is concluded that TIBC and plasma iron concentration play role on anemia and erythropoietic response to darbepoetin alfa treatment in CKD dogs.

著者

Chutimon THANABOONNIPAT Saikaew SUTAYATRAM Chollada BURANAKARL Nan CHOISUNIRACHON

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0496, (Released:2020-06-18)

被引用文献数

4

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Chronic kidney disease (CKD) is a common renal disease in dogs and cats. Renal fibrosis is a main pathologic process leading of CKD progression. Renal biopsy is the gold standard for renal fibrosis assessment. However, it is not routinely performed in clinic due to its invasiveness. Therefore, the aim of this study was to evaluate the use of ultrasonographic strain elastography (SE), which is a non-invasive method for renal tissue stiffness determination and its association with renal function. Renal strain ratios and renal function were evaluated in 13 CKD dogs (CKDD), 38 healthy dogs (HD), 17 CKD cats (CKDC) and 26 healthy cats (HC). There were significantly lower renal cortical strain ratios than medullary strain ratios in all groups (HD; P<0.01, HC; P<0.01, CKDD and CKDC; P<0.05) and significantly lower cortical and medullary strain ratios in both CKDD and CKDC than in healthy control animals of both species (P<0.0001). In dogs, the renal cortical and medullary strain ratios significantly negatively correlated with plasma creatinine (P<0.05), blood urea nitrogen (BUN; P<0.05; P<0.01, respectively), and symmetric dimethylarginine (SDMA; P<0.01). In cats, similar correlations were found for plasma creatinine (P<0.001), BUN (P<0.05; P<0.001, respectively) and SDMA (P<0.05). SE might be a promising imaging diagnostic tool for renal-elasticity evaluation, also correlating with renal functional impairment in canine and feline CKD.