- 著者
- Miki Hashimoto Hidehiro Itonaga Yasuhito Nannya Hirokazu Taniguchi Yuichi Fukuda Takafumi Furumoto Machiko Fujioka Sachie Kasai Masataka Taguchi Hiroaki Taniguchi Shinya Sato Yasushi Sawayama Sunao Atogami Keisuke Iwasaki Tomoko Hata Hiroshi Soda Yukiyoshi Moriuchi Koh Nakata Seishi Ogawa Yasushi Miyazaki
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.59, no.8, pp.1081-1086, 2020-04-15 (Released:2020-04-15)
- 参考文献数
- 31
- 被引用文献数
- 2 4
Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.