著者

Shiho Toyama Ayuko Takatani Tomohiro Koga Mizuna Eguchi Momoko Okamoto Sosuke Tsuji Yushiro Endo Toshimasa Shimizu Remi Sumiyoshi Takashi Igawa Shin-ya Kawashiri Naoki Iwamoto Kunihiro Ichinose Mami Tamai Hideki Nakamura Tomoki Origuchi Masako Furuyama Maiko Tabuchi Shinichiro Kobayashi Kengo Kanetaka Mikiko Hashisako Kuniko Abe Daisuke Niino Shinya Sato Yasushi Miyazaki Atsushi Kawakami

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2782-19, (Released:2019-07-22)

参考文献数

20

被引用文献数

1

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A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment.

著者

宮崎 康支 デキキス ジョー Yasushi Miyazaki Joseph DeChicchis

雑誌

総合政策研究 (ISSN:1341996X)

巻号頁・発行日

no.42, pp.31-40, 2013-02-20

著者

宮崎 康支 Yasushi Miyazaki

雑誌

総合政策研究 (ISSN:1341996X)

巻号頁・発行日

no.52, pp.53-67, 2016-09-20

著者

Miki Hashimoto Hidehiro Itonaga Yasuhito Nannya Hirokazu Taniguchi Yuichi Fukuda Takafumi Furumoto Machiko Fujioka Sachie Kasai Masataka Taguchi Hiroaki Taniguchi Shinya Sato Yasushi Sawayama Sunao Atogami Keisuke Iwasaki Tomoko Hata Hiroshi Soda Yukiyoshi Moriuchi Koh Nakata Seishi Ogawa Yasushi Miyazaki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.59, no.8, pp.1081-1086, 2020-04-15 (Released:2020-04-15)

参考文献数

31

被引用文献数

2 4

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Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.

著者

Tetsuya Tagami Hironori Kimura Sumire Ohtani Tsuyoshi Tanaka Takashi Tanaka Shiro Hata Miho Saito Yasushi Miyazaki Rika Araki Masami Tanaka Kazuya Yonezawa Morio Sawamura Takuyuki Ise Atsushi Ogo Takuro Shimbo Akira Shimatsu Mitsuhide Naruse

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.58, no.6, pp.449-457, 2011 (Released:2011-06-30)

参考文献数

44

被引用文献数

13 26

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Hypercholesterolemia is one of the most representative disorders of the common diseases. To evaluate the prevalence of hypothyroidism in the population of adult hypercholesterolemia, we prospectively examined the thyroid function in patients with untreated or treated hypercholesterolemia as a multi-center survey. Subjects were the patients who were treated with some antilipemic agents or the untreated patients whose total cholesterol (TC) was over 220 mg/dL and/or LDL-cholesterol (LDL-C) over 140 mg/dL. Among 737 cases recruited, 725 cases (300 males and 425 females) participated in the survey including the thyroid function test. The patient's backgrounds include hypertension (51%), diabetes mellitus (49%), fatty liver (17%), smoking (15%), and habitual drinking (10%). The 72% of the patients were treated with some antilipemic agents and the mean values of TC, LDL-C, triglyceride (TG), HDL-cholesterol (HDL-C), and LDL-C/HDL-C ratio (L/H) were 204.5 mg/dL, 119.6 mg/dL, 144.4 mg/dL, 60.7 mg/dL and 2.25, respectively. The primary hypothyroidism was seen in 27 cases (3.7%) (11 males, 16 females) with subclinical hypothyroidism in 17 cases (2.4%) and overt hypothyroidism in 10 cases (1.4%). The central hypothyroidism was seen in 4 cases (0.6%). The prevalence of hypothyroidism was 4.3% in patients with hypercholesterolemia. Taking account of the large number of patients with dyslipidemia and importance of avoiding unnecessary administration and associated adverse effects, evaluation of the thyroid function could be warranted in patients with dyslipidemia although cost-benefit issues waits further investigation.

著者

宮崎 康支 Yasushi Miyazaki

出版者

関西学院大学総合政策学部研究会

雑誌

Journal of policy studies = 総合政策研究 (ISSN:1341996X)

巻号頁・発行日

no.52, pp.53-67, 2016-09